Secretagogue
A secretagogue is a substance that causes another substance to be secreted.
One example is gastrin,[1] which stimulates the H/K ATPase in the parietal cells (increased gastric acid production by the stomach). Pentagastrin, a synthetic gastrin, histamine, and acetylcholine are also gastric secretagogues.
Insulin secretagogues, such as sulfonylureas, trigger insulin release by direct action on the KATP channel of the pancreatic beta cells. Blockage of this channel leads to depolarization and secretion of vesicles.
Angiotensin II is a secretagogue for aldosterone from the adrenal gland.
References
- Secretagogue at eMedicine Dictionary Archived October 15, 2012, at the Wayback Machine
External links
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.