Securinine
Securinine is an alkaloid found in Securinega suffruticosa[1] and Phyllanthus niruri.[2]
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| ECHA InfoCard | 100.222.962  |
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| Formula | C13H15NO2 |
| Molar mass | 217.268 g·mol−1 |
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Pharmacology
Securinine has been discontinued from pharmacological use in clinical practice for the treatment of polio and facial nerve palsy because of its adverse effects. Securinine is a GABA-A antagonist.[3]
See also
References
- Wang D, Fang L, Du G (2018). "Securinine". Natural small molecule drugs from plants. Springer Singapore. pp. 325–330. doi:10.1007/978-981-10-8022-7_54. ISBN 978-981-10-8021-0.
- Patel JR, Tripathi P, Sharma V, Chauhan NS, Dixit VK (November 2011). "Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review". Journal of Ethnopharmacology. 138 (2): 286–313. doi:10.1016/j.jep.2011.09.040. PMID 21982793.
- "Securinine". PubChem, US National Library of Medicine. 2020-07-04.
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