Selenophosphate synthetase 1

Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.[5][6]

SEPHS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSEPHS1, SELD, SPS, SPS1, Selenophosphate synthetase 1
External IDsOMIM: 600902 MGI: 1923580 HomoloGene: 56558 GeneCards: SEPHS1
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10p13Start13,317,428 bp[1]
End13,348,298 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

22929

109079

Ensembl

ENSG00000086475

ENSMUSG00000026662

UniProt

P49903
Q5T5U7

Q8BH69

RefSeq (mRNA)

NM_001195602
NM_001195604
NM_012247
NM_001375769
NM_001375770

NM_175400

RefSeq (protein)

NP_001182531
NP_001182533
NP_036379
NP_001362698

NP_780609
NP_001349636
NP_001349637
NP_001349638
NP_001349639

Location (UCSC)Chr 10: 13.32 – 13.35 MbChr 2: 4.88 – 4.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This protein encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000086475 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026662 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Low SC; Harney JW; Berry MJ (Oct 1995). "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis". J Biol Chem. 270 (37): 21659–64. doi:10.1074/jbc.270.37.21659. PMID 7665581.
  6. "Entrez Gene: SEPHS1 selenophosphate synthetase 1".

Further reading

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