Slx1 structure-specific endonuclease subunit homolog b (s. cerevisiae)

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) is a protein in humans that is encoded by the SLX1B gene. [4]

SLX1B
Identifiers
Aliases	SLX1B, GIYD2, Slx1 structure-specific endonuclease subunit homolog b, SLX1 homolog B, structure-specific endonuclease subunit
External IDs	OMIM: 615823 MGI: 1915220 HomoloGene: 11434 GeneCards: SLX1B
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 29,454,501 bp[1] End 29,458,219 bp[1]
Gene ontology Molecular function • nuclease activity • endonuclease activity • GO:0001948 protein binding • hydrolase activity • metal ion binding • 5'-flap endonuclease activity • endodeoxyribonuclease activity • crossover junction endodeoxyribonuclease activity Cellular component • cell nucleus • nucleoplasm • Slx1-Slx4 complex Biological process • DNA double-strand break processing involved in repair via single-strand annealing • cellular response to DNA damage stimulus • DNA recombination • interstrand cross-link repair • positive regulation of t-circle formation • nucleic acid phosphodiester bond hydrolysis • DNA repair • double-strand break repair via homologous recombination • telomere maintenance via telomere lengthening • t-circle formation • negative regulation of telomere maintenance via telomere lengthening • telomeric D-loop disassembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79008	75764
Ensembl	ENSG00000181625	ENSMUSG00000059772
UniProt	Q9BQ83	Q8BX32
RefSeq (mRNA)	NM_178044 NM_024044	NM_029420
RefSeq (protein)	NP_001014999 NP_001015000	NP_083696
Location (UCSC)	Chr 16: 29.45 – 29.46 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. [provided by RefSeq, Nov 2010].