Society for Industrial Microbiology and Biotechnology

The first Symposium on Biotechnology for Fuels and Chemicals was held in 1978 and hosted by Oak Ridge National Laboratory (Oak Ridge, TN). It was the first technical meeting focusing exclusively on the biotechnologically-­‐mediated conversion of renewable feedstocks, especially lignocellulosic plant biomass, to fuels and chemicals. This annual meeting soon became large enough to be co-­‐hosted by the predecessor of the National Renewable Energy Laboratory (Golden, CO) and the Symposium’s location alternated yearly between Tennessee and Colorado. In 2008, SIMB began handling the logistics of the meeting and locations were expanded to include other states, with the Symposium being held in alternate years in the eastern or western United States.

Although there has been a steady decline in natural product discovery efforts in the pharmaceutical industry over the last three decades, natural product chemical scaffolds have continued to yield important human antimicrobial agents, immunomodulators, and antitumor agents, as well as plant crop protectants. Natural product discovery is currently undergoing a renaissance based to a large extent on the observations from microbial genome sequencing projects indicating that only a fraction of the potential microbial secondary metabolites from actinomycetes, other eubacteria, and fungi have been discovered so far, and that most secondary metabolite pathways are not expressed under normal laboratory growth conditions. However, the new discipline of “genome mining” has been exploring ways to activate the expression of these “cryptic pathways.”