Stratifin

Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the SFN gene in humans.[5][6] The protein is named for its presence in stratified epithelial cells.[5]

SFN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSFN, YWHAS, Stratifin
External IDsOMIM: 601290 MGI: 1891831 HomoloGene: 4475 GeneCards: SFN
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p36.11Start26,863,149 bp[1]
End26,864,456 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2810

55948

Ensembl

ENSG00000175793

ENSMUSG00000047281

UniProt

P31947

O70456

RefSeq (mRNA)

NM_006142

NM_018754

RefSeq (protein)

NP_006133

NP_061224

Location (UCSC)Chr 1: 26.86 – 26.86 MbChr 4: 133.6 – 133.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

Stratifin has been shown to interact with PLK4,[7] ERRFI1,[8] MARK3,[7][8] JUB[8] and YWHAG.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000175793 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000047281 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Leffers H, Madsen P, Rasmussen HH, Honoré B, Andersen AH, Walbum E, Vandekerckhove J, Celis JE (June 1993). "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway". Journal of Molecular Biology. 231 (4): 982–98. doi:10.1006/jmbi.1993.1346. PMID 8515476.
  6. "Entrez Gene: SFN stratifin".
  7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  8. Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.

Further reading


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