Succinate-semialdehyde dehydrogenase (acylating)
Succinate-semialdehyde dehydrogenase (acylating) (EC 1.2.1.76, succinyl-coA reductase, coenzyme-A-dependent succinate-semialdehyde dehydrogenase) is an enzyme with systematic name succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating).[1][2][3] This enzyme catalyses the following chemical reaction
- succinate semialdehyde + CoA + NADP+ succinyl-CoA + NADPH + H+
| Succinate-semialdehyde dehydrogenase (acylating) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.2.1.76 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.
References
- Söhling B, Gottschalk G (February 1993). "Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri". European Journal of Biochemistry. 212 (1): 121–7. doi:10.1111/j.1432-1033.1993.tb17641.x. PMID 8444151.
- Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hügler M, Fuchs G (December 2006). "Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp" (PDF). Journal of Bacteriology. 188 (24): 8551–9. doi:10.1128/JB.00987-06. PMC 1698253. PMID 17041055.
- Berg IA, Kockelkorn D, Buckel W, Fuchs G (December 2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science. 318 (5857): 1782–6. doi:10.1126/science.1149976. PMID 18079405.
External links
- Succinate-semialdehyde+dehydrogenase+(acylating) at the US National Library of Medicine Medical Subject Headings (MeSH)
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