Sulfadoxine
Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria.[1]
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| ECHA InfoCard | 100.017.732  |
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| Formula | C12H14N4O4S |
| Molar mass | 310.33 g·mol−1 |
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| Melting point | 190 to 194 °C (374 to 381 °F) |
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It is also used to prevent malaria[2] but due to high levels of resistance, this use is becoming less common.[3]
It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.
Mechanism of action
Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.
See also
References
- Medical Treatment - Sulphadoxine and Pyrimethamine Archived 2007-12-28 at the Wayback Machine.
- https://www.who.int/malaria/areas/preventive_therapies/pregnancy/en/
- Matondo SI, Temba GS, Kavishe AA, et al. (2014). "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania". Malar J. 13: 152. doi:10.1186/1475-2875-13-152. PMC 3998221. PMID 24751352.
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