Synaptojanin 1

Synaptojanin 1 is a protein that in humans is encoded by the SYNJ1 gene. [5]

SYNJ1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSYNJ1, INPP5G, PARK20, synaptojanin 1, EIEE53
External IDsOMIM: 604297 MGI: 1354961 HomoloGene: 48252 GeneCards: SYNJ1
Gene location (Human)
Chr.Chromosome 21 (human)[1]
Band21q22.11Start32,628,759 bp[1]
End32,728,048 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8867

104015

Ensembl

ENSG00000159082

ENSMUSG00000022973

UniProt

O43426

Q8CHC4

RefSeq (mRNA)

NM_203446
NM_001160302
NM_001160306
NM_003895

NM_001045515
NM_001164483

RefSeq (protein)

NP_001153774
NP_001153778
NP_003886
NP_982271

n/a

Location (UCSC)Chr 21: 32.63 – 32.73 MbChr 16: 90.94 – 91.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene.

References

  1. GRCh38: Ensembl release 89: ENSG00000159082 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022973 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Synaptojanin 1". Retrieved 2016-03-13.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.