Synaptojanin 1

SYNJ1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W80, 2DNR, 2VJ0
Identifiers
Aliases	SYNJ1, INPP5G, PARK20, synaptojanin 1, EIEE53
External IDs	OMIM: 604297 MGI: 1354961 HomoloGene: 48252 GeneCards: SYNJ1
Gene location (Human)
Chr.	Chromosome 21 (human)[1]
End	32,728,048 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	91,011,308 bp[2]
Gene ontology
Molecular function	• RNA binding; • nucleic acid binding; • phosphoric ester hydrolase activity; • hydrolase activity; • phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; • phosphatidylinositol phosphate 4-phosphatase activity; • inositol-1,4,5-trisphosphate 5-phosphatase activity; • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; • phosphatidylinositol-4-phosphate phosphatase activity; • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; • phosphatidylinositol-3-phosphatase activity; • phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; • phosphatidylinositol phosphate 5-phosphatase activity; • GO:0001948 protein binding; • SH3 domain binding;
Cellular component	• cytoplasm; • membrane coat; • vesicle membrane; • presynapse; • synaptic membrane; • clathrin coat of coated pit; • terminal bouton; • microtubules; • perinuclear region of cytoplasm; • cytosol; • neuron projection; • postsynapse;
Biological process	• endocytosis; • phosphatidylinositol metabolic process; • inositol phosphate metabolic process; • learning; • synaptic vesicle uncoating; • synaptic vesicle priming; • phosphatidylinositol biosynthetic process; • synaptic vesicle transport; • neurotransmitter transport; • inositol phosphate dephosphorylation; • phosphatidylinositol dephosphorylation; • positive regulation of endosome organization; • phosphatidylinositol-3-phosphate biosynthetic process; • membrane organization; • synaptic vesicle endocytosis; • brain development; • positive regulation of gliogenesis; • response to retinoic acid; • response to cytokine; • positive regulation of receptor-mediated endocytosis; • postsynaptic neurotransmitter receptor internalization;
	Sources:Amigo / QuickGO
Orthologs
	8867
	104015
	ENSG00000159082
	ENSMUSG00000022973
	O43426
	Q8CHC4
	NM_203446; NM_001160302; NM_001160306; NM_003895
	NM_001045515; NM_001164483
	NP_001153774; NP_001153778; NP_003886; NP_982271
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptojanin 1 is a protein that in humans is encoded by the SYNJ1 gene. [5]

Function

This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene.

References

GRCh38: Ensembl release 89: ENSG00000159082 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022973 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Synaptojanin 1". Retrieved 2016-03-13.

Synaptojanin 1

Function

References

Further reading