TAC4

Tachykinin-4 is a protein that in humans is encoded by the TAC4 gene.[3][4][5]

TAC4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2MOC
Identifiers
Aliases	TAC4, EK, HK-1, HK1, PPT-C, tachykinin 4 (hemokinin), tachykinin 4, tachykinin precursor 4
External IDs	OMIM: 607833 HomoloGene: 89219 GeneCards: TAC4
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 49,838,309 bp[1] End 49,848,017 bp[1]
Gene ontology Molecular function • receptor binding • substance P receptor binding • substance K receptor binding • receptor ligand activity Cellular component • extracellular region • extracellular Biological process • regulation of blood pressure • inflammatory response • cell-cell signaling • negative regulation of systemic arterial blood pressure • tachykinin receptor signaling pathway • regulation of receptor activity • detection of temperature stimulus involved in sensory perception of pain • regulation of sensory perception of pain • positive regulation of flagellated sperm motility • negative regulation of sensory perception of pain • positive regulation of sensory perception of pain • positive regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	255061	n/a
Ensembl	ENSG00000176358	n/a
UniProt	Q86UU9	n/a
RefSeq (mRNA)	NM_170685 NM_001077503 NM_001077504 NM_001077505 NM_001077506	n/a
RefSeq (protein)	NP_001070971 NP_001070972 NP_001070973 NP_001070974 NP_733786	n/a
Location (UCSC)	Chr 17: 49.84 – 49.85 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.[5]