TAPS (buffer)

TAPS
Names
	IUPAC name 3-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}propane-1-sulfonic acid
	Other names N-Tris(hydroxymethyl)methyl-3-aminopropanesulfonic acid
Identifiers
CAS Number	29915-38-6 ;
3D model (JSmol)	Interactive image;
ChemSpider	108495 ;
ECHA InfoCard	100.045.398
PubChem CID	121591;
UNII	Y5DC3IN066 ;
CompTox Dashboard (EPA)	DTXSID3067528 ;
	InChI InChI=1S/C7H17NO6S/c9-4-7(5-10,6-11)8-2-1-3-15(12,13)14/h8-11H,1-6H2,(H,12,13,14) Key: YNLCVAQJIKOXER-UHFFFAOYSA-N ; InChI=1/C7H17NO6S/c9-4-7(5-10,6-11)8-2-1-3-15(12,13)14/h8-11H,1-6H2,(H,12,13,14) Key: YNLCVAQJIKOXER-UHFFFAOYAP;
	SMILES C(CNC(CO)(CO)CO)CS(=O)(=O)O;
Properties
Chemical formula	C7H17NO6S
Molar mass	243.27 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

TAPS ([tris(hydroxymethyl)methylamino]propanesulfonic acid) is a chemical compound commonly used to make buffer solutions.

It can bind divalent cations, including Co(II) and Ni(II).[1]

TAPS is effective to make buffer solutions in the pH range 7.7–9.1, since it has a pK_a value of 8.44 (ionic strength I = 0, 25 °C).[2]

The pH (and pK_a at I ≠ 0) of the buffer solution changes with concentration and temperature, and this effect may be predicted e.g. using online calculators.[3]

References

Machado, Carina M. M.; Gameiro, Paula; Soares, Helena M. V. M. (2008). "Complexation of M–(buffer)_x–(OH)_y systems involving divalent ions (cobalt or nickel) and zwitterionic biological buffers (AMPSO, DIPSO, TAPS and TAPSO) in aqueous solution". J. Solution Chem. 37 (5): 603–617. doi:10.1007/s10953-008-9265-3.
Goldberg, Robert N.; Kishore, Nand; Lennen, Rebecca M. (2002). "Thermodynamic quantities for the ionization reactions of buffers" (PDF). J. Phys. Chem. Ref. Data. 31 (2): 231–370. doi:10.1063/1.1416902.
"Biological buffers". REACH Devices.

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[1] Machado, Carina M. M.; Gameiro, Paula; Soares, Helena M. V. M. (2008). "Complexation of M–(buffer)_x–(OH)_y systems involving divalent ions (cobalt or nickel) and zwitterionic biological buffers (AMPSO, DIPSO, TAPS and TAPSO) in aqueous solution". J. Solution Chem. 37 (5): 603–617. doi:10.1007/s10953-008-9265-3.

[2] Goldberg, Robert N.; Kishore, Nand; Lennen, Rebecca M. (2002). "Thermodynamic quantities for the ionization reactions of buffers" (PDF). J. Phys. Chem. Ref. Data. 31 (2): 231–370. doi:10.1063/1.1416902.

[3] "Biological buffers". REACH Devices.