TBCE

Tubulin-specific chaperone E is a protein that in humans is encoded by the TBCE gene.[4][5]

TBCE
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTBCE, HRD, KCS, KCS1, pac2, tubulin folding cofactor E, PEAMO
External IDsOMIM: 604934 MGI: 1917680 HomoloGene: 37744 GeneCards: TBCE
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6905

70430

Ensembl

ENSG00000116957

ENSMUSG00000039233

UniProt

Q15813

Q8CIV8

RefSeq (mRNA)

NM_003193
NM_001079515
NM_001287801
NM_001287802

NM_178337

RefSeq (protein)

NP_001072983
NP_001274730
NP_001274731
NP_003184

NP_848027

Location (UCSC)n/aChr 13: 14 – 14.04 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene.[5]

The TBCE gene is either deleted or mutated in Sanjad-Sakati Syndrome

References

  1. GRCm38: Ensembl release 89: ENSMUSG00000039233 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ (Sep 1996). "Pathway leading to correctly folded beta-tubulin". Cell. 86 (2): 287–96. doi:10.1016/S0092-8674(00)80100-2. PMID 8706133. S2CID 18359371.
  5. "Entrez Gene: TBCE tubulin folding cofactor E".

Further reading

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