TCEA2

Transcription elongation factor A protein 2 is a protein that in humans is encoded by the TCEA2 gene.[5][6][7]

TCEA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTCEA2, TFIIS, transcription elongation factor A2
External IDsOMIM: 604784 MGI: 107368 HomoloGene: 68304 GeneCards: TCEA2
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.33Start64,049,836 bp[1]
End64,072,347 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6919

21400

Ensembl

ENSG00000171703

ENSMUSG00000059540

UniProt

Q15560
Q6IB64

Q9QVN7

RefSeq (mRNA)

NM_003195
NM_198723

NM_009326
NM_001356342
NM_001356343

RefSeq (protein)

NP_003186
NP_942016
NP_003186.1

NP_033352
NP_001343271
NP_001343272

Location (UCSC)Chr 20: 64.05 – 64.07 MbChr 2: 181.68 – 181.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

TCEA2 has been shown to interact with MAGEA11.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000171703 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000059540 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Weaver ZA, Kane CM (Dec 1997). "Genomic characterization of a testis-specific TFIIS (TCEA2) gene". Genomics. 46 (3): 516–9. doi:10.1006/geno.1997.5073. PMID 9441762.
  6. Umehara T, Kida S, Yamamoto T, Horikoshi M (Dec 1995). "Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II". Gene. 167 (1–2): 297–302. doi:10.1016/0378-1119(95)00634-6. PMID 8566795.
  7. "Entrez Gene: TCEA2 transcription elongation factor A (SII), 2".
  8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

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