TCF7

TCF7
Identifiers
Aliases	TCF7, TCF-1, transcription factor 7 (T-cell specific, HMG-box), transcription factor 7
External IDs	OMIM: 189908 HomoloGene: 135816 GeneCards: TCF7
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	134,151,865 bp[1]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• sequence-specific DNA binding; • DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001948 protein binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • beta-catenin binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• nuclear euchromatin; • transcription regulator complex; • cell nucleus; • nucleoplasm; • nuclear body;
Biological process	• cellular response to interleukin-4; • regulation of transcription, DNA-templated; • T cell receptor V(D)J recombination; • negative regulation of transcription from RNA polymerase II promoter; • embryonic hindgut morphogenesis; • Wnt signaling pathway; • transcription, DNA-templated; • canonical Wnt signaling pathway involved in negative regulation of apoptotic process; • embryonic genitalia morphogenesis; • regulation of cell proliferation; • immune response; • neural tube development; • embryonic digestive tract morphogenesis; • alpha-beta T cell differentiation; • beta-catenin-TCF complex assembly; • regulation of transcription from RNA polymerase II promoter; • canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6932
	n/a
	ENSG00000081059
	n/a
	P36402
	n/a
NM_001134851; NM_001134852; NM_003202; NM_201632; NM_201634;
	NM_213648; NM_001346425; NM_001346450; NM_001366502
	n/a
NP_001128323; NP_001333354; NP_001333379; NP_003193; NP_963963;
	NP_963965; NP_998813; NP_001353431
	n/a
	Wikidata
View/Edit Human

Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.[3]

References

GRCh38: Ensembl release 89: ENSG00000081059 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)".

van de Wetering M, Oosterwegel M, Holstege F, et al. (1992). "The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization". J. Biol. Chem. 267 (12): 8530–6. PMID 1569101.
van de Wetering M, Oosterwegel M, Dooijes D, Clevers H (1991). "Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box". EMBO J. 10 (1): 123–32. doi:10.1002/j.1460-2075.1991.tb07928.x. PMC 452620. PMID 1989880.
Castrop J, van Wichen D, Koomans-Bitter M, et al. (1995). "The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes". Blood. 86 (8): 3050–9. doi:10.1182/blood.V86.8.3050.3050. PMID 7579399.
Mayer K, Wolff E, Clevers H, Ballhausen WG (1995). "The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA". Biochim. Biophys. Acta. 1263 (2): 169–72. doi:10.1016/0167-4781(95)00108-s. PMID 7640309.
Van de Wetering M, Castrop J, Korinek V, Clevers H (1996). "Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties". Mol. Cell. Biol. 16 (3): 745–52. doi:10.1128/mcb.16.3.745. PMC 231054. PMID 8622675.
Korinek V, Barker N, Willert K, et al. (1998). "Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse". Mol. Cell. Biol. 18 (3): 1248–56. doi:10.1128/MCB.18.3.1248. PMC 108837. PMID 9488439.
Roose J, Molenaar M, Peterson J, et al. (1998). "The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors". Nature. 395 (6702): 608–12. doi:10.1038/26989. PMID 9783587. S2CID 4347003.
Roose J, Huls G, van Beest M, et al. (1999). "Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1". Science. 285 (5435): 1923–6. doi:10.1126/science.285.5435.1923. PMID 10489374.
Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related co-repressors". Nucleic Acids Res. 29 (7): 1410–9. doi:10.1093/nar/29.7.1410. PMC 31284. PMID 11266540.
Batlle E, Henderson JT, Beghtel H, et al. (2002). "Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB". Cell. 111 (2): 251–63. doi:10.1016/S0092-8674(02)01015-2. PMID 12408869. S2CID 10103038.
Noble JA, White AM, Lazzeroni LC, et al. (2003). "A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes". Diabetes. 52 (6): 1579–82. doi:10.2337/diabetes.52.6.1579. PMID 12765974.
Ioannidis V, Kunz B, Tanamachi DM, et al. (2003). "Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1". J. Immunol. 171 (2): 769–75. doi:10.4049/jimmunol.171.2.769. PMID 12847244.
Smit L, Baas A, Kuipers J, et al. (2004). "Wnt activates the Tak1/Nemo-like kinase pathway". J. Biol. Chem. 279 (17): 17232–40. doi:10.1074/jbc.M307801200. PMID 14960582.
Smith SS, Patterson T, Pauza ME (2005). "Transgenic Ly-49A inhibits antigen-driven T cell activation and delays diabetes". J. Immunol. 174 (7): 3897–905. doi:10.4049/jimmunol.174.7.3897. PMID 15778344.
Willinger T, Freeman T, Herbert M, et al. (2006). "Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo". J. Immunol. 176 (3): 1439–46. doi:10.4049/jimmunol.176.3.1439. PMID 16424171.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000081059 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)".

TCF7

References

Further reading