TDRD7

Tudor domain-containing protein 7 is a protein that in humans is encoded by the TDRD7 gene.[5][6]

TDRD7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTDRD7, CATC4, CTRCT36, PCTAIRE2BP, TRAP, tudor domain containing 7
External IDsOMIM: 611258 MGI: 2140279 HomoloGene: 8618 GeneCards: TDRD7
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q22.33Start97,412,096 bp[1]
End97,496,125 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23424

100121

Ensembl

ENSG00000196116

ENSMUSG00000035517

UniProt

Q8NHU6

Q8K1H1

RefSeq (mRNA)

NM_001302884
NM_014290

NM_001290475
NM_146142
NM_001355189

RefSeq (protein)

NP_001289813
NP_055105

NP_001277404
NP_666254
NP_001342118

Location (UCSC)Chr 9: 97.41 – 97.5 MbChr 4: 45.97 – 46.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

In melanocytic cells TDRD7 gene expression may be regulated by MITF.[7]

Gene polymorphism

Various single nucleotide polymorphisms (SNPs) of the TDRD7 gene have been identified and for some of them an association with lower susceptibility to age-related cataract was shown.[8]

Interactions

TDRD7 has been shown to interact with TACC1.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000196116 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035517 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. "Entrez Gene: TDRD7 tudor domain containing 7".
  7. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
  8. Zheng C, Wu M, He CY, An XJ, Sun M, Chen CL, Ye J (Feb 2014). "RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract". J. Int. Med. Res. 42 (1): 153–63. doi:10.1177/0300060513504702. PMID 24435515.
  9. Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q8NHU6 (Human Tudor domain-containing protein 7) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: Q8K1H1 (Mouse Tudor domain-containing protein 7) at the PDBe-KB.
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