TELO2

TELO2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PSI
Identifiers
Aliases	TELO2, CLK2, TEL2, telomere maintenance 2, YHFS
External IDs	OMIM: 611140 MGI: 1918968 HomoloGene: 41107 GeneCards: TELO2
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	1,510,457 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	25,115,967 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0032947 molecular adaptor activity; • Hsp90 protein binding; • GO:0001948 protein binding; • protein kinase binding; • GO:0032403 macromolecular complex binding; • telomeric DNA binding;
Cellular component	• cytoplasm; • chromosome, telomeric region; • TORC1 complex; • TORC2 complex; • intracellular; • membrane; • nuclear periphery; • cell nucleus; • chromosome; • cytosol; • nuclear body; • nuclear chromosome, telomeric region; • ASTRA complex;
Biological process	• positive regulation of TORC1 signaling; • protein stabilization; • regulation of TOR signaling; • positive regulation of TORC2 signaling; • positive regulation of protein serine/threonine kinase activity; • telomere maintenance;
	Sources:Amigo / QuickGO
Orthologs
	9894
	71718
	ENSG00000100726
	ENSMUSG00000024170
	Q9Y4R8
	Q9DC40
	NM_016111; NM_001351846
	NM_001163661; NM_027880
	NP_057195; NP_001338775
	NP_001157133; NP_082156
	Wikidata
View/Edit Human	View/Edit Mouse

Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene.[5][6][7][8]

Function

In 2007, researchers reported an unexpected role for Tel2 in the expression of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs). Although Tel2 was identified as a budding yeast gene required for the telomere length maintenance, they found no obvious telomeric function for mammalian Tel2. Tel2 deletion also curbed mTOR signaling, indicating that Tel2 affects mammalian PIKKs. Tel2 binds to part of the HEAT repeat segments of ATM and mTOR, and is a highly conserved regulator of PIKK stability.[9]

References

GRCh38: Ensembl release 89: ENSG00000100726 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024170 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J Biol Chem. 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.
"Entrez Gene: TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)".
Takai H, Wang R, Takai K, Yang H, De Lange T (2007). "Tel2 Regulates the Stability of PI3K-Related Protein Kinases". Cell. 131 (7): 1248–1259. doi:10.1016/j.cell.2007.10.052. PMID 18160036. S2CID 6297247.

External links

Overview of all the structural information available in the PDB for UniProt: Q9Y4R8 (Human Telomere length regulation protein TEL2 homolog) at the PDBe-KB.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100726 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024170 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid11230166-6] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[pmid12670948-7] Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J Biol Chem. 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.

[entrez-8] "Entrez Gene: TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)".

[TakaiEtAl-9] Takai H, Wang R, Takai K, Yang H, De Lange T (2007). "Tel2 Regulates the Stability of PI3K-Related Protein Kinases". Cell. 131 (7): 1248–1259. doi:10.1016/j.cell.2007.10.052. PMID 18160036. S2CID 6297247.

TELO2

Function

References

Further reading

External links