TERRA (biology)

TERRA in biology is an abbreviation for "TElomeric Repeat-containing RNA".[1] TERRA is RNA that is transcribed from telomeres the repeating 6-nucleotide sequences that cap the ends of chromosomes. TERRA functions with shelterin to inhibit telomere lengthening by enzyme telomerase.[1]

TERRAs are essential for telomere length and maintenance.[2] At least four factors contribute to telomere maintenance: telomerase, shelterin, TERRA and the CST Complex.[3]

TERRA can also regulate telomere length by increasing euchromatin formation.[4] On the other hand, nonsense-mediated decay factor enrichment at telomeres may exist to prevent TERRA inhibition of telomerase.[1] TERRA levels vary during the cell cycle, decreasing during S phase, and increasing in the transition from G2 phase to G1 phase.[4]

References


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.