TIPIN

TIPIN
Identifiers
Aliases	TIPIN, TIMELESS interacting protein
External IDs	OMIM: 610716 MGI: 1921571 HomoloGene: 32373 GeneCards: TIPIN
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	66,386,746 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	64,305,424 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • DNA binding;
Cellular component	• intracellular membrane-bounded organelle; • nuclear chromatin; • cell nucleus; • nucleoplasm; • cytoplasm; • replication fork protection complex;
Biological process	• cell cycle phase transition; • intra-S DNA damage checkpoint; • cellular response to DNA damage stimulus; • cell division; • DNA replication checkpoint; • regulation of nuclear cell cycle DNA replication; • positive regulation of cell proliferation; • cell cycle; • replication fork arrest; • replication fork protection; • DNA damage checkpoint; • response to UV; • DNA replication;
	Sources:Amigo / QuickGO
Orthologs
	54962
	66131
	ENSG00000075131
	ENSMUSG00000032397
	Q9BVW5
	Q91WA1
	NM_001289986; NM_017858
	NM_025372; NM_001324556; NM_001324557; NM_001324558
	NP_001276915; NP_060328
	NP_001311485; NP_001311486; NP_001311487; NP_079648
	Wikidata
View/Edit Human	View/Edit Mouse

TIMELESS-interacting protein is a protein that in humans is encoded by the TIPIN gene.[5][6][7]

Interactions

GRCh38: Ensembl release 89: ENSG00000075131 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032397 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Gotter AL (Aug 2003). "Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association". Journal of Molecular Biology. 331 (1): 167–76. doi:10.1016/S0022-2836(03)00633-8. PMID 12875843.
Yoshizawa-Sugata N, Masai H (Jan 2007). "Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint". The Journal of Biological Chemistry. 282 (4): 2729–40. doi:10.1074/jbc.M605596200. PMID 17102137.
"Entrez Gene: TIPIN TIMELESS interacting protein".
Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.

Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.
Gotter AL, Suppa C, Emanuel BS (Feb 2007). "Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors". Journal of Molecular Biology. 366 (1): 36–52. doi:10.1016/j.jmb.2006.10.097. PMC 4151250. PMID 17141802.
Chou DM, Elledge SJ (Nov 2006). "Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function". Proceedings of the National Academy of Sciences of the United States of America. 103 (48): 18143–7. doi:10.1073/pnas.0609251103. PMC 1654129. PMID 17116885.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

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