TIPIN

TIMELESS-interacting protein is a protein that in humans is encoded by the TIPIN gene.[5][6][7]

TIPIN
Identifiers
AliasesTIPIN, TIMELESS interacting protein
External IDsOMIM: 610716 MGI: 1921571 HomoloGene: 32373 GeneCards: TIPIN
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q22.31Start66,336,191 bp[1]
End66,386,746 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

54962

66131

Ensembl

ENSG00000075131

ENSMUSG00000032397

UniProt

Q9BVW5

Q91WA1

RefSeq (mRNA)

NM_001289986
NM_017858

NM_025372
NM_001324556
NM_001324557
NM_001324558

RefSeq (protein)

NP_001276915
NP_060328

NP_001311485
NP_001311486
NP_001311487
NP_079648

Location (UCSC)Chr 15: 66.34 – 66.39 MbChr 9: 64.28 – 64.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

TIPIN has been shown to interact with Replication protein A1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000075131 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032397 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gotter AL (Aug 2003). "Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association". Journal of Molecular Biology. 331 (1): 167–76. doi:10.1016/S0022-2836(03)00633-8. PMID 12875843.
  6. Yoshizawa-Sugata N, Masai H (Jan 2007). "Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint". The Journal of Biological Chemistry. 282 (4): 2729–40. doi:10.1074/jbc.M605596200. PMID 17102137.
  7. "Entrez Gene: TIPIN TIMELESS interacting protein".
  8. Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.

Further reading

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