TLL2

Tolloid-like protein 2 is a protein that in humans is encoded by the TLL2 gene.[5][6]

TLL2
Identifiers
AliasesTLL2, tolloid like 2
External IDsOMIM: 606743 MGI: 1346044 HomoloGene: 56545 GeneCards: TLL2
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q24.1Start96,364,608 bp[1]
End96,513,926 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

7093

24087

Ensembl

ENSG00000095587

ENSMUSG00000025013

UniProt

Q9Y6L7

Q9WVM6

RefSeq (mRNA)

NM_012465

NM_011904

RefSeq (protein)

NP_036597

NP_036034

Location (UCSC)Chr 10: 96.36 – 96.51 MbChr 19: 41.08 – 41.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000095587 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025013 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19". Cytogenet Cell Genet. 86 (1): 64–5. doi:10.1159/000015412. PMID 10516436. S2CID 42081614.
  6. "Entrez Gene: TLL2 tolloid-like 2".

Further reading


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