TMEM165

Transmembrane protein 165 is a protein that in humans is encoded by the TMEM165 gene.[1] The gene is also known as TPARL and TMPT27.[1]

Model organisms

Model organisms have been used in the study of TMEM165 function. A conditional knockout mouse line, called Tmem165tm1e(EUCOMM)Wtsi[7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][11] Twenty three tests were carried out on mutant mice and two significant abnormalities were observed.[5] Homozygous mutant males had skeletal deformities, including scoliosis, and an increased susceptibility to bacterial infection.[5]

References
  1. "Transmembrane protein 165". Retrieved 2011-12-06.
  2. "Radiography data for Tmem165". Wellcome Trust Sanger Institute.
  3. "Salmonella infection data for Tmem165". Wellcome Trust Sanger Institute.
  4. "Citrobacter infection data for Tmem165". Wellcome Trust Sanger Institute.
  5. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  6. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. "International Knockout Mouse Consortium".
  8. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  11. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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