TNRC6A

Trinucleotide repeat-containing gene 6A protein is a protein that in humans is encoded by the TNRC6A gene.[5][6]

TNRC6A
Identifiers
AliasesTNRC6A, CAGH26, GW1, GW182, TNRC6, trinucleotide repeat containing 6A, FAME6, trinucleotide repeat containing adaptor 6A
External IDsOMIM: 610739 MGI: 2385292 HomoloGene: 41399 GeneCards: TNRC6A
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p12.1Start24,610,209 bp[1]
End24,827,632 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

27327

233833

Ensembl

ENSG00000090905
ENSG00000288130

ENSMUSG00000052707

UniProt

Q8NDV7

Q3UHK8

RefSeq (mRNA)

NM_014494
NM_001330520
NM_001351850

NM_144925

RefSeq (protein)

NP_001317449
NP_055309
NP_001338779

NP_659174

Location (UCSC)Chr 16: 24.61 – 24.83 MbChr 7: 123.12 – 123.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.[6]

References

  1. ENSG00000288130 GRCh38: Ensembl release 89: ENSG00000090905, ENSG00000288130 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000052707 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.
  6. "Entrez Gene: TNRC6A trinucleotide repeat containing 6A".

Further reading

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