TNS1
Tensin-1 is a protein that in humans is encoded by the TNS1 gene.[5]
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| Aliases | TNS1, MST091, MST122, MST127, MSTP122, MSTP127, MXRA6, PPP1R155, TNS, MSTP091, tensin 1 | ||||||||||||||||||||||||
| External IDs | OMIM: 600076 MGI: 104552 HomoloGene: 11219 GeneCards: TNS1 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr 2: 217.8 – 218 Mb | Chr 1: 73.91 – 74.12 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
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The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.[5]
References
- GRCh38: Ensembl release 89: ENSG00000079308 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000055322 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: TNS1 tensin 1".
External links
- TNS1 Info with links in the Cell Migration Gateway
Further reading
- Jankowski SA, Gumucio DL (1996). "Genes for tensin, villin and desmin are linked on mouse chromosome 1" (PDF). Mamm. Genome. 6 (10): 744–5. doi:10.1007/BF00354299. hdl:2027.42/47016. PMID 8563175. S2CID 22316923.
- Salgia R, Pisick E, Sattler M, et al. (1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". J. Biol. Chem. 271 (41): 25198–203. doi:10.1074/jbc.271.41.25198. PMID 8810278.
- Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
- Katz BZ, Zohar M, Teramoto H, et al. (2000). "Tensin can induce JNK and p38 activation". Biochem. Biophys. Res. Commun. 272 (3): 717–20. doi:10.1006/bbrc.2000.2853. PMID 10860821.
- Chen H, Ishii A, Wong WK, et al. (2001). "Molecular characterization of human tensin". Biochem. J. 351 Pt 2 (2): 403–11. doi:10.1042/0264-6021:3510403. PMC 1221376. PMID 11023826.
- Benzing T, Gerke P, Höpker K, et al. (2001). "Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9784–9. doi:10.1073/pnas.171269898. PMC 55530. PMID 11493697.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Yamashita M, Horikoshi S, Asanuma K, et al. (2004). "Tensin is potentially involved in extracellular matrix production in mesangial cells". Histochem. Cell Biol. 121 (3): 245–54. doi:10.1007/s00418-004-0626-8. PMID 14991332. S2CID 5634607.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Eto M, Kirkbride J, Elliott E, et al. (2007). "Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions". J. Biol. Chem. 282 (24): 17806–15. doi:10.1074/jbc.M700944200. PMID 17435217.
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