TOB2

Protein Tob2 is a protein that in humans is encoded by the TOB2 gene.[5][6][7]

TOB2
Identifiers
AliasesTOB2, TOB4, TOBL, TROB2, transducer of ERBB2, 2, APRO5
External IDsOMIM: 607396 MGI: 1888525 HomoloGene: 9447 GeneCards: TOB2
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.2Start41,433,494 bp[1]
End41,446,801 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10766

57259

Ensembl

ENSG00000183864

ENSMUSG00000048546

UniProt

Q14106

Q9JM55

RefSeq (mRNA)

NM_016272

NM_020507

RefSeq (protein)

NP_057356

NP_065253

Location (UCSC)Chr 22: 41.43 – 41.45 MbChr 15: 81.85 – 81.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM][7]

Interactions

TOB2 has been shown to interact with CNOT7.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000183864 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000048546 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (Jan 2000). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.
  6. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  7. "Entrez Gene: TOB2 transducer of ERBB2, 2".

Further reading


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