TRNA (pseudouridine54-N1)-methyltransferase

TRNA (pseudouridine54-N1)-methyltransferase (EC 2.1.1.257, TrmY, m1Psi methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (pseudouridine54-N1)-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + pseudouridine54 in tRNA S-adenosyl-L-homocysteine + N1-methylpseudouridine54 in tRNA
TRNA (pseudouridine54-N1)-methyltransferase
Identifiers
EC number2.1.1.257
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This archaeal enzyme is specific for the 54 position.

References
  1. Chen HY, Yuan YA (December 2010). "Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase". Journal of Molecular Cell Biology. 2 (6): 366–74. doi:10.1093/jmcb/mjq034. PMID 21098051.
  2. Wurm JP, Griese M, Bahr U, Held M, Heckel A, Karas M, Soppa J, Wöhnert J (March 2012). "Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs". RNA. 18 (3): 412–20. doi:10.1261/rna.028498.111. PMC 3285930. PMID 22274954.
  3. Chatterjee K, Blaby IK, Thiaville PC, Majumder M, Grosjean H, Yuan YA, Gupta R, de Crécy-Lagard V (March 2012). "The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA". RNA. 18 (3): 421–33. doi:10.1261/rna.030841.111. PMC 3285931. PMID 22274953.
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