TTF2

Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.[5][6]

TTF2
Identifiers
AliasesTTF2, HuF2, ZGRF6, transcription termination factor, RNA polymerase II, transcription termination factor 2
External IDsOMIM: 604718 MGI: 1921294 HomoloGene: 37826 GeneCards: TTF2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p13.1Start117,060,326 bp[1]
End117,107,453 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8458

74044

Ensembl

ENSG00000116830

ENSMUSG00000033222

UniProt

Q9UNY4

Q5NC05

RefSeq (mRNA)

NM_003594

NM_001013026

RefSeq (protein)

NP_003585

NP_001013044

Location (UCSC)Chr 1: 117.06 – 117.11 MbChr 3: 100.94 – 100.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.[6]

Interactions

TTF2 has been shown to interact with CDC5L.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000116830 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033222 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Liu M, Xie Z, Price DH (October 1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member". The Journal of Biological Chemistry. 273 (40): 25541–4. doi:10.1074/jbc.273.40.25541. PMID 9748214.
  6. "Entrez Gene: TTF2 transcription termination factor, RNA polymerase II".
  7. Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.

Further reading


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