TUBA1B

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.[4][5][6]

TUBA1B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTUBA1B, K-ALPHA-1, tubulin alpha 1b
External IDsOMIM: 602530 MGI: 107804 HomoloGene: 134527 GeneCards: TUBA1B
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.12Start49,127,782 bp[1]
End49,131,397 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10376

22143

Ensembl

ENSG00000123416

ENSMUSG00000023004

UniProt

P68363

P05213

RefSeq (mRNA)

NM_006082

NM_011654

RefSeq (protein)

NP_006073

NP_035784

Location (UCSC)Chr 12: 49.13 – 49.13 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

TUBA1B has been shown to interact with PIK3R1.[7] Antibodies against tubulin alpha 1b can be used as markers for microtubules and spindles.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000123416 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Banerjee A (Jun 2002). "Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells". Biochem Biophys Res Commun. 293 (1): 598–601. doi:10.1016/S0006-291X(02)00269-3. PMID 12054644.
  5. Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (Jan 1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Mol Cell Biol. 3 (10): 1738–45. doi:10.1128/mcb.3.10.1738. PMC 370035. PMID 6646120.
  6. "Entrez Gene: TUBA1B tubulin, alpha 1b".
  7. Kapeller, R; Toker A; Cantley L C; Carpenter C L (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". J. Biol. Chem. UNITED STATES. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. ISSN 0021-9258. PMID 7592789.
  8. https://www.genetex.com/Product/Detail/alpha-Tubulin-antibody-GT114/GTX628802

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.