TWF2

Twinfilin-2 is a protein that in humans is encoded by the TWF2 gene.[5][6][7]

TWF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTWF2, A6RP, A6r, PTK9L, MSTP011, twinfilin actin binding protein 2
External IDsOMIM: 607433 MGI: 1346078 HomoloGene: 5272 GeneCards: TWF2
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p21.2Start52,228,612 bp[1]
End52,239,158 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

11344

23999

Ensembl

ENSG00000247596

ENSMUSG00000023277

UniProt

Q6IBS0

Q9Z0P5

RefSeq (mRNA)

NM_007284

NM_011876

RefSeq (protein)

NP_009215

NP_036006

Location (UCSC)Chr 3: 52.23 – 52.24 MbChr 9: 106.2 – 106.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000247596 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023277 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rohwer A, Kittstein W, Marks F, Gschwendt M (Aug 1999). "Cloning, expression and characterization of an A6-related protein". Eur J Biochem. 263 (2): 518–25. doi:10.1046/j.1432-1327.1999.00537.x. PMID 10406962.
  6. Vartiainen MK, Sarkkinen EM, Matilainen T, Salminen M, Lappalainen P (Sep 2003). "Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated". J Biol Chem. 278 (36): 34347–55. doi:10.1074/jbc.M303642200. PMID 12807912.
  7. "Entrez Gene: TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila)".

Further reading

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