TYSND1

Function

This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome.

The encoded protein is also capable of cleaving several proteins targeted to peroxisomes through the C-terminal peroxisomal targeting signal (PTS1). The full-length protein undergoes self-cleavage to produce shorter, potentially inactive fragments. Alternative splicing results in multiple transcript variants for this gene.

References

  1. GRCh38: Ensembl release 89: ENSG00000156521 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020087 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Trypsin domain containing 1". Retrieved 2017-10-02.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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