The Viper Room

Despite the death of Phoenix the year the venue opened, the club became and remained a hangout for Hollywood's most popular young actors and musicians. Regulars included Jennifer Aniston, Lisa Marie Presley, Alyssa Wright, Jared Leto, Christina Applegate, Angelina Jolie, Rosario Dawson, Tobey Maguire, Drew Barrymore and Leonardo DiCaprio. Adam Duritz, the lead singer of Counting Crows, worked as a Viper Room bartender in late 1994 and early 1995 to escape his newfound fame.[7] Johnny Cash performed at the venue, debuting material that would later appear on American Recordings (1994).[8] In 1997, the Viper Room was also a place of a few early solo live performances by John Frusciante at the time of his bad physical condition caused by drug abuse. The Pussycat Dolls performed there from 1995 to 2001.

At Depp's request, Tom Petty and the Heartbreakers performed on the club's opening night.[9] The Viper Room continues to frequently host metal and punk rock bands.

In the 1983 film Valley Girl, the building (then housing a nightclub called The Central) was used for scenes featuring the new-wave band the Plimsouls. In Oliver Stone's film The Doors (1991), the building was used as a filming location for scenes depicting the London Fog, also of West Hollywood. London Fog was a lesser-known nightclub halfway up the same block from the Whisky a Go Go where the Doors had their first regular gigs for four months in early 1966.[10]

The 2003 Charlie's Angels: Full Throttle "Pink Panther Dance" scene was filmed at the club, though the club's name was changed in the film to "The Treasure Chest".

Several scenes in the 2005 John Travolta film Be Cool were set at or in the club,[11][12] although only the exterior of the site was used in the shoot.[13]

The Viper Room is also featured in the 2004 documentary DiG! when members of the band the Brian Jonestown Massacre began brawling with each other on stage while performing.

As part of the settlement of a lawsuit involving the disappearance of co-owner Anthony Fox in December 2001, Depp relinquished his ownership of the Viper Room in 2004.[14] The club changed hands multiple times between 2004 and 2016; the club is currently owned by Viper Room Holdings, Ltd. CEO James Cooper and Silver Creek Development.[15][16]

A nightclub located in Cincinnati, Ohio, was formerly called "The Viper Room". The club changed its name to "The Poison Room" on January 1, 2006, after they were told by the West Hollywood Viper Room to stop using the name.[17] Another "Viper Room" in Portland, Oregon, has also been told to stop using the name under threat of a trademark lawsuit, with the Viper Room's former owner claiming "Every dollar they make is the result of using our name."[18] Additionally, there is a legal brothel in Brisbane, Australia called "The Viper Room". There is also a nightclub in Stockholm, Sweden, "as well as ones in Harrogate, UK, Vienna, Austria, and another in Sheffield UK similarly named." Until February 2009 there was a nightclub with the same name in Melbourne, Australia; it was closed down due to a spate of violent incidents that included two shootings as well as license breaches and the arrest of a co-owner on drug charges.[19] On April 16, 2011, a nightclub named "The Viper Room" opened its doors in the city of Nijmegen in the Netherlands. The club is named after the club in Hollywood and is decorated in the same style as the American club.[20] In 2016, The Viper Room began issuing cease and desist notices to bootleg merchandise sellers on eBay and other online storefronts.