Theresa M. Reineke
Theresa M. Reineke (born January 1, 1972) is an American chemist and Distinguished McKnight University Professor at the University of Minnesota. She designs sustainable, environmentally friendly polymer-based delivery systems for targeted therapeutics. She is the Associate Editor of ACS Macro Letters.
Early life and education
Reineke earned her bachelor's degree at University of Wisconsin–Eau Claire.[1] She moved to Arizona State University for her graduate studies and earned a Master's degree in 1998.[1][2] Reineke was a PhD student at the University of Michigan, where she was supervised by Michael O'Keeffe and Omar M. Yaghi.[1][3] She was awarded the Wirt and Mary Cornell Prize for Outstanding Graduate Research. Reineke joined the California Institute of Technology as an National Institutes of Health postdoctoral fellow in 2000.[1]
Research and career
Reineke joined the University of Minnesota in 2011. Her research group focus on the design, characterisation and functionalisation of macromolecular systems.[4][5] These macromolecules include biocompatible polymers that can deliver DNA for regenerative medicine as well as targeted therapeutic treatments.[4] She was made a Lloyd H. Reyerson Professor with tenure at the University of Minnesota in 2011.[1] Reineke has published over 140 papers.
Nucleic acids can have an unparalleled specificity for targets inside a cell, but need to be compacted into nanostructures (polyplexes) that can enter cells.[6] Reineke designs polymer-based transportation systems for nucleic acids.[6] These polymer vehicles can improve the solubility and bioavailability of drugs.[7] These often incorporate carbohydrates, which have an affinity for polyplexes and are non-toxic.[6] She is a member of the University of Minnesota Centre for Sustainable Polymers, synthesising polymers from sustainable ingredients. The carbohydrate units within her polymer drug delivery systems are a widely available, renewable resource.[8] The sustainable polymers designed by Reineke include poly(ester-thioethers).[8]
Reineke used reversible addition−fragmentation chain-transfer polymerization for the synthesis of diblock terpolymers that can be used for targeted drug delivery.[9] She used spray dried dispersions of the polymer with the drug probucol.[10]
Reineke was made a University of Minnesota Distinguished McKnight University Professor in 2017.[1] She is the Associate Editor of ACS Macro Letters and on the Advisory Board of Biomacromolecules, Bioconjugate Chemistry and Polymer Chemistry.[11] She is a member of the American Chemical Society Polymer Division.[12] Her work has been supported by an National Science Foundation CAREER Award, a Sloan Research Fellowship, the National Institutes of Health and the National Academy of Sciences.
Awards and honors
- 2000 Outstanding Graduate Research Award from the Wirt and Mary Cornell Prize[1]
- 2003 American Chemical Society (PMSE Division), Arthur K. Doolittle Award[13]
- 2007 YWCA Rising Star[1]
- 2007 OH Bioscience Thirty in Their 30s Award[1]
- 2012 American Society of Gene and Cell Therapy Outstanding New Investigator Award[14]
- 2012 American Chemical Society, Polymer Materials: Science and Engineering Division Macro 2012 Lecture Award[15]
- 2016 American Institute for Medical and Biological Engineering Fellow[16]
- 2016 University of Minnesota Sara Evans Faculty Woman Scholar/Leader Award[17]
- 2016 University of Minnesota George W. Taylor Award for Distinguished Research[18]
- 2017 American Chemical Society Polymer Chemistry Division Carl S. Marvel Creative Polymer Chemistry Award[19]
- 2018 Danisco Foundation DuPont Nutrition and Health Science Excellence Medal[20][21]
- 2018 American Chemical Society POLY Fellow Award[22]
- 2018 Big 10 Alliance Academic Leadership Program Fellow[23]
Patents
External links
References
- "Dr. Theresa M. Reineke". The Reineke Group. Retrieved 2019-04-17.
- "Nonviral Synthetic Polymers Promote Cellular and In Vivo Delivery of Therapeutic Genes and Editing Systems". Breakthrough Symposium. Retrieved 2019-04-17.
- "Chemistry Tree – Theresa M. Reineke". academictree.org. Retrieved 2019-04-17.
- "Research". The Reineke Group. Retrieved 2019-04-17.
- Aldevron (2018-12-04), Theresa Reineke; Breakthrough Symposium Presenter, retrieved 2019-04-17
- "Nucleic Acid Delivery". The Reineke Group. Retrieved 2019-04-17.
- Stanford, © Stanford University; Notice, California 94305 Copyright Complaints Trademark. "2019 Winter Talk (Theresa M. Reineke, University of Minnesota) | Stanford Polymer Collective". web.stanford.edu. Retrieved 2019-04-17.
- "Sustainable Polymers". The Reineke Group. Retrieved 2019-04-17.
- "Oral Drug Delivery". The Reineke Group. Retrieved 2019-04-17.
- Tale, Swapnil; Purchel, Anatolii A.; Dalsin, Molly C.; Reineke, Theresa M. (2017-09-22). "Diblock Terpolymers Are Tunable and pH Responsive Vehicles To Increase Hydrophobic Drug Solubility for Oral Administration". Molecular Pharmaceutics. 14 (11): 4121–4127. doi:10.1021/acs.molpharmaceut.7b00458. ISSN 1543-8384. PMID 28937226.
- "Dr. Theresa M. Reineke". The Reineke Group. Retrieved 2019-04-17.
- "Reineke – address". old.polyacs.org. Retrieved 2019-04-17.
- "Faculty Awards". www.artsci.uc.edu. Retrieved 2019-04-17.
- "Outstanding New Investigator Awards | ASGCT – American Society of Gene & Cell Therapy | ASGCT – American Society of Gene & Cell Therapy". www.asgct.org. Retrieved 2019-04-17.
- "MP's Reineke receives Macro 2012 Lecture Award | IPRIME". iprime.umn.edu. Retrieved 2019-04-17.
- "Theresa M. Reineke, Ph.D. COF-2038 – AIMBE". Retrieved 2019-04-17.
- "Reineke selected 2016 Sara Evans Faculty Woman Scholar | Center for Sustainable Polymers". Retrieved 2019-04-17.
- "Theresa Reinke, of IPrime's polymer group, receives Talyor Award for Distinguished Research | IPRIME". www.iprime.umn.edu. Retrieved 2019-04-17.
- "Carl S. Marvel Award for Creative Polymer Chemistry". Division of Polymer Chemistry, Inc. 2017-11-28. Retrieved 2019-04-17.
- "DuPont Nutrition & Health Honors 2018 Science Excellence and Microbiome Science Award Medalists – DuPont | Danisco". www.dupontnutritionandhealth.com. Retrieved 2019-04-17.
- harva015 (2018-10-11). "Reineke honored with DuPont Nutrition & Health Science Excellence Medal". Department of Chemistry. Retrieved 2019-04-17.
- harva015 (2018-02-22). "Professor Reineke named a 2018 POLY Fellow". Department of Chemistry. Retrieved 2019-04-17.
- "News | MRSEC". mrsec.umn.edu. Retrieved 2019-04-17.
- "US Patent for Monomers, polymers and articles containing the same from sugar derived compounds Patent (Patent # 9,505,778 issued November 29, 2016) – Justia Patents Search". patents.justia.com. Retrieved 2019-04-17.
- "US Patent for Isosorbide-based polymethacrylates Patent (Patent # 9,988,393 issued June 5, 2018) – Justia Patents Search". patents.justia.com. Retrieved 2019-04-17.