Tight junction protein 2

Tight junction protein ZO-2 is a protein that in humans is encoded by the TJP2 gene.[5]

TJP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTJP2, C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2, Tight junction protein 2
External IDsOMIM: 607709 MGI: 1341872 HomoloGene: 3541 GeneCards: TJP2
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q21.11Start69,121,264 bp[1]
End69,274,615 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9414

21873

Ensembl

ENSG00000119139

ENSMUSG00000024812

UniProt

Q9UDY2

Q9Z0U1

RefSeq (mRNA)

NM_001198985
NM_011597
NM_001360391
NM_001360392
NM_001376368

RefSeq (protein)

NP_001163885
NP_001163886
NP_001163887
NP_004808
NP_963923

NP_001185914
NP_035727
NP_001347320
NP_001347321

Location (UCSC)Chr 9: 69.12 – 69.27 MbChr 19: 24.09 – 24.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton [supplied by OMIM].[6]

Interactions

Tight junction protein 2 has been shown to interact with tight junction protein 1,[7][8][9] band 4.1,[10] occludin[7][8][11] and USP53.[12]

References

  1. GRCh38: Ensembl release 89: ENSG00000119139 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024812 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Duclos F, Rodius F, Wrogemann K, Mandel JL, Koenig M (November 1994). "The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb". Hum Mol Genet. 3 (6): 909–914. doi:10.1093/hmg/3.6.909. PMID 7951235.
  6. "Entrez Gene: TJP2 tight junction protein 2 (zona occludens 2)".
  7. Itoh, M; Morita K; Tsukita S (February 1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin". J. Biol. Chem. 274 (9): 5981–5986. doi:10.1074/jbc.274.9.5981. ISSN 0021-9258. PMID 10026224.
  8. Wittchen, E S; Haskins J; Stevenson B R (December 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". J. Biol. Chem. 274 (49): 35179–35185. doi:10.1074/jbc.274.49.35179. ISSN 0021-9258. PMID 10575001.
  9. Fanning, A S; Jameson B J; Jesaitis L A; Anderson J M (November 1998). "The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton". J. Biol. Chem. 273 (45): 29745–29753. doi:10.1074/jbc.273.45.29745. ISSN 0021-9258. PMID 9792688.
  10. Mattagajasingh, S N; Huang S C; Hartenstein J S; Benz E J (September 2000). "Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton". J. Biol. Chem. 275 (39): 30573–30585. doi:10.1074/jbc.M004578200. ISSN 0021-9258. PMID 10874042.
  11. Peng, Bi-Hung; Lee J Ching; Campbell Gerald A (December 2003). "In vitro protein complex formation with cytoskeleton-anchoring domain of occludin identified by limited proteolysis". J. Biol. Chem. 278 (49): 49644–49651. doi:10.1074/jbc.M302782200. ISSN 0021-9258. PMID 14512431.
  12. Kazmierczak M, Harris SL, Kazmierczak P, Shah P, Starovoytov V, Ohlemiller KK, Schwander M (November 2015). "Progressive Hearing Loss in Mice Carrying a Mutation in Usp53". The Journal of Neuroscience. 35 (47): 15582–98. doi:10.1523/JNEUROSCI.1965-15.2015. PMC 4659823. PMID 26609154.

Further reading

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