Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase

Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (EC 4.1.2.45, 2'-hydroxybenzalpyruvate aldolase, NsaE, tHBPA hydratase-aldolase) is an enzyme with systematic name (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate hydro-lyase.[1][2][3][4] This enzyme catalyses the following chemical reaction

(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O salicylaldehyde + pyruvate
Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
Identifiers
EC number4.1.2.45
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is involved in naphthalene degradation.

References
  1. Kuhm AE, Knackmuss HJ, Stolz A (May 1993). "Purification and properties of 2'-hydroxybenzalpyruvate aldolase from a bacterium that degrades naphthalenesulfonates". The Journal of Biological Chemistry. 268 (13): 9484–9. PMID 8486638.
  2. Keck A, Conradt D, Mahler A, Stolz A, Mattes R, Klein J (July 2006). "Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6". Microbiology. 152 (Pt 7): 1929–40. doi:10.1099/mic.0.28783-0. PMID 16804169.
  3. Eaton RW (December 1994). "Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid". Journal of Bacteriology. 176 (24): 7757–62. doi:10.1128/jb.176.24.7757-7762.1994. PMC 197239. PMID 8002605.
  4. Eaton RW (June 2000). "trans-o-Hydroxybenzylidenepyruvate hydratase-aldolase as a biocatalyst". Applied and Environmental Microbiology. 66 (6): 2668–72. doi:10.1128/aem.66.6.2668-2672.2000. PMC 110598. PMID 10831455.
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