Tyrosine-ester sulfotransferase
In enzymology, a tyrosine-ester sulfotransferase (EC 2.8.2.9) is an enzyme that catalyzes the chemical reaction
- 3'-phosphoadenylyl sulfate + L-tyrosine methyl ester adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate
| tyrosine-ester sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.2.9 | ||||||||
| CAS number | 9055-56-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and L-tyrosine methyl ester, whereas its two products are adenosine 3',5'-bisphosphate and L-tyrosine methyl ester 4-sulfate.
This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase. Other names in common use include aryl sulfotransferase IV, and L-tyrosine methyl ester sulfotransferase.
References
- Duffel MW, Jakoby WB (1981). "On the mechanism of aryl sulfotransferase". J. Biol. Chem. 256 (21): 11123–7. PMID 6945304.
- Mattock P, Jones JG (1970). "Partial purification and properties of an enzyme from rat liver that catalyses the sulphation of L-tyrosyl derivatives". Biochem. J. 116 (5): 797–803. PMC 1185501. PMID 5441369.
- Sekura RD, Jakoby WB (1981). "Aryl sulfotransferase IV from rat liver". Arch. Biochem. Biophys. 211 (1): 352–9. doi:10.1016/0003-9861(81)90464-1. PMID 6946725.
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