U6atac minor spliceosomal RNA

U6atac minor spliceosomal RNA is a non-coding RNA which is an essential component of the minor U12-type spliceosome complex. The U12-type spliceosome is required for removal of the rarer class of eukaryotic introns (AT-AC, U12-type).[1]

U6atac minor spliceosomal RNA
Identifiers
SymbolU6atac
RfamRF00619
Other data
RNA typeGene; snRNA; splicing
Domain(s)Eukaryota
GOGO:0000355 GO:0000369 GO:0030622 GO:0030627 GO:0005691
SOSO:0000274
PDB structuresPDBe

U6atac snRNA is proposed to form a base-paired complex with another spliceosomal RNA U4atac via two stem loop regions. These interacting stem loops have been shown to be required for in vivo splicing.[2] U6atac is the functional analog of U6 spliceosomal RNA in the major U2-type spliceosomal complex.[2]

References

  1. Lorkovic ZJ, Lehner R, Forstner C, Barta A (2005). "Evolutionary conservation of minor U12-type spliceosome between plants and humans". RNA. 11 (7): 1095–1107. doi:10.1261/rna.2440305. PMC 1370794. PMID 15987817.
  2. Padgett RA, Shukla GC (2002). "A revised model for U4atac/U6atac snRNA base pairing". RNA. 8 (2): 125–128. doi:10.1017/S1355838202017156. PMC 1370236. PMID 11911359.


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