U7 small nuclear RNA

The U7 small nuclear RNA (U7 snRNA) is an RNA molecule and a component of the small nuclear ribonucleoprotein complex (U7 snRNP). The U7 snRNA is required for histone pre-mRNA processing.

U7 small nuclear RNA
Identifiers
SymbolU7
RfamRF00066
Other data
RNA typeGene; snRNA
Domain(s)Eukaryota
SOSO:0000274
PDB structuresPDBe

The 5' end of the U7 snRNA binds the HDE (histone downstream element), a conserved purine-rich region, located 15 nucleotides downstream the histone mRNA cleavage site.[1][2] The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future recruitment of cleavage factors during histone pre-mRNA processing.[3]

See also

References
  1. Spycher C, Streit A, Stefanovic B, Albrecht D, Koning TH, Schümperli D (1994). "3' end processing of mouse histone pre-mRNA: evidence for additional base-pairing between U7 snRNA and pre-mRNA". Nucleic Acids Res. 22 (20): 4023–4030. doi:10.1093/nar/22.20.4023. PMC 331885. PMID 7937126.
  2. Mowry KL, Steitz JA (1987). "Identification of the human U7 snRNP as one of several factors involved in the 3' end maturation of histone premessenger RNA's". Science. 238 (4834): 1682–1687. doi:10.1126/science.2825355. PMID 2825355.
  3. Marzluff, William F.; Wagner, Eric J.; Duronio, Robert J. (2008). "Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail". Nature Reviews Genetics. 9 (11): 843–854. doi:10.1038/nrg2438. PMC 2715827. PMID 18927579.

Further reading
  1. Voigt T, Meyer K, Baum O, Schümperli D (2010). "Ultrastructural changes in diaphragm neuromuscular junctions in a severe mouse model for Spinal Muscular Atrophy and their prevention by bifunctional U7 snRNA correcting SMN2 splicing". Neuromuscul Disord. 20 (11): 744–752. doi:10.1016/j.nmd.2010.06.010. PMID 20832308.
  2. Ruepp MD, Vivarelli S, Pillai RS, Kleinschmidt N, Azzouz TN, Barabino SM, Schümperli D (2010). "The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs". Nucleic Acids Res. 38 (21): 7637–7650. doi:10.1093/nar/gkq613. PMC 2995043. PMID 20634199.
  3. Geib T, Hertel KJ (2009). Valcarcel, Juan (ed.). "Restoration of full-length SMN promoted by adenoviral vectors expressing RNA antisense oligonucleotides embedded in U7 snRNAs". PLoS ONE. 4 (12): e8204. doi:10.1371/journal.pone.0008204. PMC 2781471. PMID 19997596.
  4. Godfrey AC, White AE, Tatomer DC, Marzluff WF, Duronio RJ (2009). "The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development". RNA. 15 (9): 1661–1672. doi:10.1261/rna.1518009. PMC 2743060. PMID 19620235.
  5. Yang XC, Torres MP, Marzluff WF, Dominski Z (2009). "Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA". Mol Cell Biol. 29 (15): 4045–4056. doi:10.1128/MCB.00296-09. PMC 2715809. PMID 19470752.
  6. Goyenvalle A, Babbs A, van Ommen GJ, Garcia L, Davies KE (2009). "Enhanced exon-skipping induced by U7 snRNA carrying a splicing silencer sequence: Promising tool for DMD therapy". Mol Ther. 17 (7): 1234–1240. doi:10.1038/mt.2009.113. PMC 2835201. PMID 19455105.
  7. Meyer K, Marquis J, Trüb J, Nlend Nlend R, Verp S, Ruepp MD, Imboden H, Barde I, Trono D, Schümperli D (2009). "Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation". Hum Mol Genet. 18 (3): 546–555. doi:10.1093/hmg/ddn382. PMID 19010792.
  8. Marquis J, Kämpfer SS, Angehrn L, Schümperli D (2009). "Doxycycline-controlled splicing modulation by regulated antisense U7 snRNA expression cassettes". Gene Ther. 16 (1): 70–77. doi:10.1038/gt.2008.138. PMID 18701908.
  9. Marz M, Mosig A, Stadler BM, Stadler PF (2007). "U7 snRNAs: a computational survey". Genomics Proteomics Bioinformatics. 5 (3–4): 187–195. doi:10.1016/S1672-0229(08)60006-6. PMC 5054213. PMID 18267300.
  10. Higuchi T, Anzai K, Kobayashi S (2008). "U7 snRNA acts as a transcriptional regulator interacting with an inverted CCAAT sequence-binding transcription factor NF-Y". Biochim Biophys Acta. 1780 (2): 274–281. doi:10.1016/j.bbagen.2007.11.005. PMID 18078822.
  11. Friend K, Lovejoy AF, Steitz JA (2007). "U2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation". Mol Cell. 28 (2): 240–252. doi:10.1016/j.molcel.2007.09.026. PMC 2149891. PMID 17964263.
  12. Uchikawa H, Fujii K, Kohno Y, Katsumata N, Nagao K, Yamada M, Miyashita T (2007). "U7 snRNA-mediated correction of aberrant splicing caused by activation of cryptic splice sites". J Hum Genet. 52 (11): 891–897. doi:10.1007/s10038-007-0192-8. PMID 17851636.
  13. Marquis J, Meyer K, Angehrn L, Kämpfer SS, Rothen-Rutishauser B, Schümperli D (2007). "Spinal muscular atrophy: SMN2 pre-mRNA splicing corrected by a U7 snRNA derivative carrying a splicing enhancer sequence". Mol Ther. 15 (8): 1479–1486. doi:10.1038/sj.mt.6300200. PMID 17505471.
  14. Asparuhova MB, Marti G, Liu S, Serhan F, Trono D, Schümperli D (2007). "Inhibition of HIV-1 multiplication by a modified U7 snRNA inducing Tat and Rev exon skipping". J Gene Med. 9 (5): 323–334. doi:10.1002/jgm.1027. PMID 17474072.
  15. Scheuerbrandt G (2006). "Exon skipping with U7 gene transfer". Acta Myol. 25 (1): 40–2. PMID 17039980.
  16. Jaeger S, Martin F, Rudinger-Thirion J, Giegé R, Eriani G (2006). "Binding of human SLBP on the 3'-UTR of histone precursor H4-12 mRNA induces structural rearrangements that enable U7 snRNA anchoring". Nucleic Acids Res. 34 (17): 4987–4995. doi:10.1093/nar/gkl666. PMC 1635294. PMID 16982637.
  17. Wagner EJ, Marzluff WF (2006). "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase". Mol Cell Biol. 26 (17): 6702–6712. doi:10.1128/MCB.00391-06. PMC 1592837. PMID 16914750.
  18. Kolev NG, Steitz JA (2006). "In vivo assembly of functional U7 snRNP requires RNA backbone flexibility within the Sm-binding site". Nat Struct Mol Biol. 13 (4): 347–353. doi:10.1038/nsmb1075. PMID 16547514.
  19. Godfrey AC, Kupsco JM, Burch BD, Zimmerman RM, Dominski Z, Marzluff WF, Duronio RJ (2006). "U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis". RNA. 12 (3): 396–409. doi:10.1261/rna.2270406. PMC 1383579. PMID 16495235.
  20. Madocsai C, Lim SR, Geib T, Lam BJ, Hertel KJ (2005). "Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs". Mol Ther. 12 (6): 1013–1022. doi:10.1016/j.ymthe.2005.08.022. PMID 16226920.
  21. Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D (2005). "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes". J Biol Chem. 280 (41): 34435–34440. doi:10.1074/jbc.M505077200. PMID 16087681.
  22. Azzouz TN, Gruber A, Schümperli D (2005). "U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA 3' end processing". Nucleic Acids Res. 33 (7): 2106–2117. doi:10.1093/nar/gki516. PMC 1075925. PMID 15824063.
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  25. Liu S, Asparuhova M, Brondani V, Ziekau I, Klimkait T, Schümperli D (2004). "Inhibition of HIV-1 multiplication by antisense U7 snRNAs and siRNAs targeting cyclophilin A". Nucleic Acids Res. 32 (12): 3752–3759. doi:10.1093/nar/gkh715. PMC 484190. PMID 15254276.
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  27. Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D (2003). "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing". Genes Dev. 17 (18): 2321–2333. doi:10.1101/gad.274403. PMC 196468. PMID 12975319.
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  29. Brun C, Suter D, Pauli C, Dunant P, Lochmüller H, Burgunder JM, Schümperli D, Weis J (2003). "U7 snRNAs induce correction of mutated dystrophin pre-mRNA by exon skipping". Cell Mol Life Sci. 60 (3): 557–566. doi:10.1007/s000180300047. PMID 12737315.
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