UCN2

Urocortin-2 is a protein that in humans is encoded by the UCN2 gene.[4][5]

UCN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUCN2, SRP, UCN-II, UCNI, UR, URP, urocortin 2
External IDsOMIM: 605902 MGI: 2176375 HomoloGene: 50048 GeneCards: UCN2
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p21.31Start48,561,718 bp[1]
End48,563,781 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

90226

171530

Ensembl

ENSG00000145040

ENSMUSG00000049699

UniProt

Q96RP3

Q99ML8

RefSeq (mRNA)

NM_033199

NM_145077

RefSeq (protein)

NP_149976

NP_659543

Location (UCSC)Chr 3: 48.56 – 48.56 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000145040 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Hsu SY, Hsueh AJ (Apr 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nat Med. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063. S2CID 22916906.
  5. "Entrez Gene: UCN2 urocortin 2".

Further reading


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