UFSP1

UFM1 specific peptidase 1 (inactive) is a protein that in humans is encoded by the UFSP1 gene.[5]

UFSP1
Identifiers
AliasesUFSP1, UFSP, UFM1-specific peptidase 1 (inactive), UFM1 specific peptidase 1 (inactive)
External IDsOMIM: 611481 MGI: 1917490 HomoloGene: 80245 GeneCards: UFSP1
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q22.1Start100,888,721 bp[1]
End100,889,715 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

402682

70240

Ensembl

ENSG00000176125

ENSMUSG00000051502

UniProt

Q6NVU6

Q9CZP0

RefSeq (mRNA)

NM_001015072

NM_027356

RefSeq (protein)

NP_001015072

NP_081632

Location (UCSC)Chr 7: 100.89 – 100.89 MbChr 5: 137.29 – 137.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009].[5]

References
  1. GRCh38: Ensembl release 89: ENSG00000176125 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000051502 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: UFM1 specific peptidase 1 (inactive)". Retrieved 2020-04-15. This article incorporates text from this source, which is in the public domain.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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