UHRF2

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.[5][6]

UHRF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUHRF2, NIRF, RNF107, URF2, TDRD23, ubiquitin like with PHD and ring finger domains 2
External IDsOMIM: 615211 MGI: 1923718 HomoloGene: 17001 GeneCards: UHRF2
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9p24.1Start6,413,151 bp[1]
End6,507,054 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

115426

109113

Ensembl

ENSG00000147854

ENSMUSG00000024817

UniProt

Q96PU4

Q7TMI3

RefSeq (mRNA)

NM_152896

NM_144873

RefSeq (protein)

NP_690856

NP_659122

Location (UCSC)Chr 9: 6.41 – 6.51 MbChr 19: 30.03 – 30.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000147854 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024817 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mori T, Li Y, Hata H, Ono K, Kochi H (Aug 2002). "NIRF, a novel RING finger protein, is involved in cell-cycle regulation". Biochem Biophys Res Commun. 296 (3): 530–6. doi:10.1016/S0006-291X(02)00890-2. PMID 12176013.
  6. "Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2".

Further reading


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