USP13

USP13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L80, 2LBC
Identifiers
Aliases	USP13, ISOT3, IsoT-3, ubiquitin specific peptidase 13 (isopeptidase T-3), ubiquitin specific peptidase 13
External IDs	OMIM: 603591 MGI: 1919857 HomoloGene: 68372 GeneCards: USP13
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	179,789,401 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	32,938,071 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• cysteine-type peptidase activity; • chaperone binding; • zinc ion binding; • BAT3 complex binding; • metal ion binding; • GO:1904454, GO:1904455 ubiquitin-like protein-specific protease activity; • proteasome binding; • peptidase activity; • ubiquitin binding; • GO:0001948 protein binding; • ubiquitin-like protein ligase binding; • hydrolase activity; • ubiquitin protein ligase binding; • thiol-dependent ubiquitin-specific protease activity; • cysteine-type endopeptidase activity;
Cellular component	• nucleoplasm; • cytosol;
Biological process	• regulation of transcription, DNA-templated; • ubiquitin-dependent protein catabolic process; • positive regulation of ERAD pathway; • proteolysis; • autophagy; • regulation of autophagy; • protein K63-linked deubiquitination; • maintenance of unfolded protein involved in ERAD pathway; • cellular proliferation; • melanocyte differentiation; • protein deubiquitination; • protein K29-linked deubiquitination; • protein K6-linked deubiquitination; • protein stabilization;
	Sources:Amigo / QuickGO
Orthologs
	8975
	72607
	ENSG00000058056
	ENSMUSG00000056900
	Q92995
	Q5BKP2
	NM_003940
	NM_001013024
	NP_003931
	NP_001013042
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 13 is an enzyme that in humans is encoded by the USP13 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000058056 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000056900 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
"Entrez Gene: USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)".

D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
Timms KM, Ansari-Lari MA, Morris W, et al. (1998). "The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP)". Gene. 217 (1–2): 101–6. doi:10.1016/S0378-1119(98)00341-2. PMID 9841226.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
McElhinny AS, Kakinuma K, Sorimachi H, et al. (2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1". J. Cell Biol. 157 (1): 125–36. doi:10.1083/jcb.200108089. PMC 2173255. PMID 11927605.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000058056 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056900 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12838346-5] Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.

[entrez-6] "Entrez Gene: USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)".

USP13

References

Further reading