USP2

USP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HD5, 2IBI, 3NHE, 3V6C, 3V6E
Identifiers
Aliases	USP2, UBP41, USP9, ubiquitin specific peptidase 2
External IDs	OMIM: 604725 MGI: 1858178 HomoloGene: 3098 GeneCards: USP2
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	119,381,711 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	44,095,627 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• cysteine-type peptidase activity; • metal ion binding; • peptidase activity; • GO:0001948 protein binding; • identical protein binding; • cysteine-type endopeptidase activity; • hydrolase activity; • ubiquitin protein ligase binding; • cyclin binding; • thiol-dependent ubiquitin-specific protease activity;
Cellular component	• cytoplasm; • centrosome; • cell cortex; • perinuclear region of cytoplasm; • cell nucleus; • nucleoplasm; • membrane;
Biological process	• ubiquitin-dependent protein catabolic process; • rhythmic process; • muscle organ development; • protein stabilization; • positive regulation of mitotic cell cycle; • negative regulation of transcription from RNA polymerase II promoter; • circadian regulation of gene expression; • proteolysis; • circadian behavior; • cell cycle; • entrainment of circadian clock by photoperiod; • locomotor rhythm; • protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	9099
	53376
	ENSG00000036672
	ENSMUSG00000032010
	O75604
	O88623
	NM_001243759; NM_004205; NM_171997
	NM_016808; NM_198091; NM_198092
	NP_001230688; NP_004196; NP_741994
	NP_058088; NP_932759; NP_932760
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 2 is an enzyme that in humans is encoded by the USP2 gene.[5][6]

Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM][6]

References

GRCh38: Ensembl release 89: ENSG00000036672 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032010 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
"Entrez Gene: USP2 ubiquitin specific peptidase 2".

D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
Baek SH, Choi KS, Yoo YJ, et al. (1997). "Molecular cloning of a novel ubiquitin-specific protease, UBP41, with isopeptidase activity in chick skeletal muscle". J. Biol. Chem. 272 (41): 25560–5. doi:10.1074/jbc.272.41.25560. PMID 9325273.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gewies A, Grimm S (2003). "UBP41 is a proapoptotic ubiquitin-specific protease". Cancer Res. 63 (3): 682–8. PMID 12566314.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Graner E, Tang D, Rossi S, et al. (2004). "The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer". Cancer Cell. 5 (3): 253–61. doi:10.1016/S1535-6108(04)00055-8. PMID 15050917.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Stevenson LF, Sparks A, Allende-Vega N, et al. (2007). "The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2". EMBO J. 26 (4): 976–86. doi:10.1038/sj.emboj.7601567. PMC 1852834. PMID 17290220.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000036672 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032010 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12838346-5] Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.

[entrez-6] "Entrez Gene: USP2 ubiquitin specific peptidase 2".

USP2

References

Further reading