Uwe Marx

Uwe Marx (born 26 June 1964) is a German physician and biotechnologist, and is one of the world's leading researchers in the fields of organ-on-a-chip technology[1][2] and antibody production.[3] In 1989, he planned to recreate organs like liver, lung, or skin in vitro and to mimic organ functions and interactions outside a living organism.[4] He was initially able to develop a human artificial lymph node model (in vitro) for immunogenicity tests.[5][6] Since 2007, Marx has been working together with other scientists to reproduce the human organism on a microfluidic chip at a scale of 1:100,000.[7] The aim is to shorten the entire drug development process as well as to reduce animal experiments and drug testing in humans during clinical trials.[8] These microfluidic devices can also be used to test other substances (e.g. chemicals, cosmetic ingredients) for their safety and efficacy.[9]

Uwe Marx
Uwe Marx in 2011
Born (1964-06-26) June 26, 1964
Berlin
NationalityGerman
Alma materCharité Berlin, University Hospital of Leipzig (Universitätsklinikum Leipzig), Technische Universität Berlin (TU Berlin)
Scientific career
FieldsOrgan-on-a-chip technology, antibody production

Marx was born in Berlin. He is the founder of the biotechnology companies Vita 34, ProBioGen,[10] and the TU Berlin spin-off TissUse.[11] Marx has authored more than 50 publications and is an inventor on more than 140 patents.[12]

Memberships

Selected honors and awards
  • (2017) Best Article Award in Annual Journal[16][17]
  • (2014) Recipient of 33rd Animal Protection Research Prize[18]
  • (2012) Recipient of Dorothy Hegarty Award for Best Article - ATLA vol 40, 2012[19]

Selected publications
  • (2016) Validation of bioreactor and human-on-a-chip devices for chemical safety assessment. (Chapter 12) Eds. Eskes and Whelan: Validating Alternative Methods for Toxicity Testing. Springer book. Rebelo, S.P.; Dehne, E.-M.; Brito, C.; Horland, R.; Alves, P.M.; Marx, U.
  • (2016) Marx et al. t4 report: "Organs and Humans-on-a-chip" – a biology-inspired microphysiological systems approach to solve the current drug development dilemma. ALTEX 33(3). 30 authors.
  • (2012) Human-on-a-chip’ Developments: A Translational Cutting edge Alternative to Systemic Safety Assessment and Efficiency Evaluation of Substances in Laboratory Animals and Man? ATLA, 40, 235-257. Marx, U.; Walles, H.; Hoffmann, S.; Lindner, G.; Horland, R.; Sonntag, F.; Klotzbach, U.; Sakharov, D.; Tonevitsky, A.; Lauster, R.

References
  1. "Human on a Chip". tu-berlin.de. Retrieved 31 May 2017.
  2. "Human Organ Farms Could Stop Animal Testing in Just 3 Years, Say Scientists". care2.com. Retrieved 31 May 2017.
  3. "Monoclonal Antibody Production, A Report of the Committee on Methods of Producing Monoclonal Antibodies" (PDF). The National Academies Press. Retrieved 31 May 2017.
  4. Marx U, Matthes H, Nagel A, von Baehr R (1993). "Application of a hollow fiber membrane cell culture system in medicine". American Biotechnology Laboratory. 11 (November): 26. PMID 7764233.
  5. "Artificial Lymph Node: Testing human specific immune reactions". ldf.org.uk. Retrieved 31 May 2017.
  6. "Artificial immune organ". patents.justia.com. Retrieved 31 May 2017.
  7. Marx U (2007). Drug Testing In Vitro: Breakthroughs and Trends in Cell Culture Technology. Wiley-Blackwell. Retrieved 30 May 2017.
  8. ""Mini-Organismus" soll Tierversuche ersetzen". welt.de. Retrieved 31 May 2017.
  9. Marx U, et al. (2016). "Biology-inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing" (PDF). Altex. 33 (May): 272–321. PMC 5396467. PMID 27180100. Retrieved 30 May 2017.
  10. "Uwe Marx M.D., Ph.D.: Executive Profile & Biography - Bloomberg". bloomberg.com. Retrieved 30 May 2017.
  11. "Uwe Marx - Scientific Founder at TissUse - Relationship Science". relationshipscience.com. Retrieved 30 May 2017.
  12. "Patents by Inventor Uwe Marx". Retrieved 31 May 2017.
  13. "Working Group Cell Culture Technology at DECHEMA". Retrieved 1 June 2017.
  14. "Supervisory Board at ProBioGen AG". Retrieved 1 June 2017.
  15. "Advisory board at Fraunhofer Institute for Cell Therapy and Immunology IZI". Retrieved 1 June 2017.
  16. "Chronicle of the ALTEX Award". ALTEX. Retrieved 1 June 2017.
  17. Marx, Uwe (2016). "Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing". ALTEX. 33 (3): 272–321. doi:10.14573/altex.1603161. PMC 5396467. PMID 27180100.
  18. "Künstliche Organ-Systeme und Zellkulturen statt Tierversuche" (in German). Federal Ministry of Food and Agriculture (Germany). 4 Dec 2014.
  19. "Dorothy Hegarty Award Winners 2012". Alternatives to Laboratory Animals. Sep 2013.
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