VPS28

Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene.[5]

VPS28
Identifiers
AliasesVPS28, ESCRT-I subunit, VPS28 subunit of ESCRT-I
External IDsOMIM: 611952 MGI: 1914164 HomoloGene: 69205 GeneCards: VPS28
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q24.3Start144,423,601 bp[1]
End144,428,563 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51160

66914

Ensembl

ENSG00000160948
ENSG00000285339

ENSMUSG00000115987

UniProt

Q9UK41
Q548N1

Q9D1C8

RefSeq (mRNA)

NM_016208
NM_183057

NM_025842
NM_001305668

RefSeq (protein)

NP_057292
NP_898880
NP_057292.1

NP_001292597
NP_080118

Location (UCSC)Chr 8: 144.42 – 144.43 MbChr 15: 76.62 – 76.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein involved in endosomal sorting of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated protein. The two other subunits of ESCRT-I are vacuolar protein sorting 23 (VPS23), also known as tumor susceptibility gene 101 (TSG101), and vacuolar protein sorting 37 (VPS37). Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally.[5]

Interactions

VPS28 has been shown to interact with TSG101.[6][7][8]

References

  1. ENSG00000285339 GRCh38: Ensembl release 89: ENSG00000160948, ENSG00000285339 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000115987 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)".
  6. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  7. Stuchell MD, Garrus JE, Müller B, Stray KM, Ghaffarian S, McKinnon R, Kräusslich HG, Morham SG, Sundquist WI (August 2004). "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding". J. Biol. Chem. 279 (34): 36059–71. doi:10.1074/jbc.M405226200. PMID 15218037.
  8. Bishop N, Woodman P (April 2001). "TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes". J. Biol. Chem. 276 (15): 11735–42. doi:10.1074/jbc.M009863200. PMID 11134028.

Further reading


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