VTI1A

VTI1A
Identifiers
Aliases	VTI1A, MMDS3, MVti1, VTI1RP2, Vti1-rp2, vesicle transport through interaction with t-SNAREs 1A
External IDs	OMIM: 614316 MGI: 1855699 HomoloGene: 39963 GeneCards: VTI1A
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	112,818,744 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	55,627,309 bp[2]
Gene ontology
Molecular function	• SNAP receptor activity; • GO:0001948 protein binding; • SNARE binding;
Cellular component	• integral component of membrane; • endosome; • Golgi apparatus; • membrane; • synaptic vesicle; • autophagosome; • neuronal cell body; • SNARE complex; • perinuclear region of cytoplasm; • neuron projection terminus; • cytoplasmic vesicle; • clathrin-coated vesicle; • trans-Golgi network membrane; • ER to Golgi transport vesicle membrane; • cytosol; • Golgi membrane; • late endosome membrane; • endoplasmic reticulum membrane; • intracellular membrane-bounded organelle;
Biological process	• voluntary musculoskeletal movement; • autophagy; • retrograde transport, endosome to Golgi; • protein transport; • intracellular protein transport; • Golgi ribbon formation; • vesicle-mediated transport; • Golgi to vacuole transport; • vesicle fusion with Golgi apparatus; • intra-Golgi vesicle-mediated transport; • ER to Golgi vesicle-mediated transport; • protein targeting to vacuole;
	Sources:Amigo / QuickGO
Orthologs
	143187
	53611
	ENSG00000151532
	ENSMUSG00000024983
	Q96AJ9
	O89116
NM_145206; NM_001318203; NM_001318205; NM_001365710; NM_001365711;
	NM_001365712; NM_001365713; NM_001365714
	NM_001293685; NM_001293686; NM_016862; NM_001360431; NM_001360432
NP_001305132; NP_001305134; NP_660207; NP_001352639; NP_001352640;
	NP_001352641; NP_001352642; NP_001352643
	NP_001280614; NP_001280615; NP_058558; NP_001347360; NP_001347361
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicle transport through interaction with t-SNAREs homolog 1A is a protein that in humans is encoded by the VTI1A gene.[5][6]

The protein encoded by the VTI1A gene is a target-SNARE (t-SNARE) protein which is located in the membranes of target vesicle compartments.

References

GRCh38: Ensembl release 89: ENSG00000151532 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024983 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: vesicle transport through interaction with t-SNAREs homolog 1A (yeast)".
Fischer von Mollard G, Stevens TH (January 1998). "A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways". J. Biol. Chem. 273 (5): 2624–30. doi:10.1074/jbc.273.5.2624. PMID 9446565.

Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene Variants Associated With Ischemic Stroke: The Cardiovascular Health Study". Stroke. 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Grupe A, Li Y, Rowland C, et al. (2006). "A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
Mallard F, Tang BL, Galli T, et al. (2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of Gene Variants with Incident Myocardial Infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Flowerdew SE, Burgoyne RD (2009). "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels". Biochem. J. 418 (3): 529–40. doi:10.1042/BJ20081736. PMC 2650881. PMID 19138172.
Tai G, Lu L, Wang TL, et al. (2004). "Participation of the Syntaxin 5/Ykt6/GS28/GS15 SNARE Complex in Transport from the Early/Recycling Endosome to the Trans-Golgi Network". Mol. Biol. Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
Antonin W, Holroyd C, Fasshauer D, et al. (2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151532 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024983 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: vesicle transport through interaction with t-SNAREs homolog 1A (yeast)".

[pmid9446565-6] Fischer von Mollard G, Stevens TH (January 1998). "A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways". J. Biol. Chem. 273 (5): 2624–30. doi:10.1074/jbc.273.5.2624. PMID 9446565.

VTI1A

References

Further reading