Vesicle-associated membrane protein 8

Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.[4][5][6]

VAMP8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVAMP8, EDB, VAMP-8, vesicle associated membrane protein 8
External IDsOMIM: 603177 MGI: 1336882 HomoloGene: 37846 GeneCards: VAMP8
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p11.2Start85,561,562 bp[1]
End85,582,031 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8673

22320

Ensembl

ENSG00000118640

ENSMUSG00000050732

UniProt

Q9BV40

O70404

RefSeq (mRNA)

NM_003761

NM_016794

RefSeq (protein)

NP_003752

NP_058074

Location (UCSC)Chr 2: 85.56 – 85.58 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex.[6] Phosphorylation of VAMP8 inside the conserved SNARE-domain can suppress vesicle fusion.[7]

Interactions

Vesicle-associated membrane protein 8 has been shown to interact with STX4,[8][9] SNAP23,[8][10] STX1A,[11] STX8[12] and STX7.[12][13]

References

  1. GRCh38: Ensembl release 89: ENSG00000118640 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Bui TD, Wong SH, Lu L, Hong W (February 1999). "Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse". Genomics. 54 (3): 579–80. doi:10.1006/geno.1998.5596. PMID 9878266.
  5. Wong SH, Zhang T, Xu Y, Subramaniam VN, Griffiths G, Hong W (July 1998). "Endobrevin, a Novel Synaptobrevin/VAMP-Like Protein Preferentially Associated with the Early Endosome". Mol Biol Cell. 9 (6): 1549–63. doi:10.1091/mbc.9.6.1549. PMC 25382. PMID 9614193.
  6. "Entrez Gene: VAMP8 vesicle-associated membrane protein 8 (endobrevin)".
  7. Malmersjö S, Di Palma S, Diao J, Lai Y, Pfuetzner RA, Wang AL, McMahon MA, Hayer A, Porteus M, Bodenmiller B, Brunger AT, Meyer T (July 2016). "Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion". EMBO Journal. 35 (16): 1721–1843. doi:10.15252/embj.201694071. PMC 5010044. PMID 27402227.
  8. Paumet, F; Le Mao J; Martin S; Galli T; David B; Blank U; Roa M (June 2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". J. Immunol. 164 (11): 5850–7. doi:10.4049/jimmunol.164.11.5850. ISSN 0022-1767. PMID 10820264.
  9. Polgár, János; Chung Sul-Hee; Reed Guy L (August 2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood. 100 (3): 1081–3. doi:10.1182/blood.V100.3.1081. ISSN 0006-4971. PMID 12130530.
  10. Imai, Akane; Nashida Tomoko; Yoshie Sumio; Shimomura Hiromi (August 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. ISSN 0003-9969. PMID 12828989.
  11. Nagamatsu, S; Nakamichi Y; Watanabe T; Matsushima S; Yamaguchi S; Ni J; Itagaki E; Ishida H (January 2001). "Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules". J. Cell Sci. 114 (Pt 1): 219–227. ISSN 0021-9533. PMID 11112705.
  12. Antonin, W; Holroyd C; Fasshauer D; Pabst S; Von Mollard G F; Jahn R (Dec 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. ISSN 0261-4189. PMC 305878. PMID 11101518.
  13. Wade, N; Bryant N J; Connolly L M; Simpson R J; Luzio J P; Piper R C; James D E (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. ISSN 0021-9258. PMID 11278762.

Further reading

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