Vitamin D and Omega-3 Trial

Vitamin D and Omega-3 Trial (VITAL) (VITamin D and OmegA-3 TriaL) is a 7 year[1] trial to run from 2010 to determine the benefits of vitamin D and Omega-3 supplements on elderly Americans.[2][3] Its estimated completion date is November 2018.[1]

It aims to enroll 20,000 participants (women 55 or over, men 50 or over)[4][5] who will be randomized to one of four groups:[3]

  • daily vitamin D (2000 IU) and fish oil (1 g);
  • daily vitamin D and fish-oil placebo;
  • daily vitamin-D placebo and fish oil;
  • daily vitamin-D placebo and fish-oil placebo.

Participants will answer annual questionnaires[3] to determine effects on risk of cancer, heart disease, stroke, osteoporosis, diabetes, memory loss and depression.

References
  1. Clinical trial number NCT01169259 for "Vitamin D and Omega-3 Trial (VITAL)" at ClinicalTrials.gov
  2. "Massive Vitamin-D/Omega-3 Trial for CVD, Cancer Prevention"
  3. VITAL Study
  4. Manson, JE.; Bassuk, SS.; Lee, IM.; Cook, NR.; Albert, MA.; Gordon, D.; Zaharris, E.; Macfadyen, JG.; et al. (Jan 2012). "The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease". Contemp Clin Trials. 33 (1): 159–71. doi:10.1016/j.cct.2011.09.009. PMC 3253961. PMID 21986389.
  5. http://www.vitalstudy.org/QA.html#eligible Retrieved April 5, 2013
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