WDR33

WD repeat-containing protein 33 is a protein that in humans is encoded by the WDR33 gene.[5][6]

WDR33
Identifiers
AliasesWDR33, NET14, WDC146, WD repeat domain 33
External IDsOMIM: 618082 MGI: 1921570 HomoloGene: 56807 GeneCards: WDR33
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q14.3Start127,701,027 bp[1]
End127,811,187 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

55339

74320

Ensembl

ENSG00000136709

ENSMUSG00000024400

UniProt

Q9C0J8

Q8K4P0

RefSeq (mRNA)

NM_001006622
NM_001006623
NM_018383

NM_001170966
NM_001170967
NM_001170970
NM_028866

RefSeq (protein)

NP_001006623
NP_001006624
NP_060853

NP_001164437
NP_001164438
NP_001164441
NP_083142

Location (UCSC)Chr 2: 127.7 – 127.81 MbChr 18: 31.8 – 31.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000136709 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024400 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ito S, Sakai A, Nomura T, Miki Y, Ouchida M, Sasaki J, Shimizu K (Feb 2001). "A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner". Biochem Biophys Res Commun. 280 (3): 656–63. doi:10.1006/bbrc.2000.4163. PMID 11162572.
  6. "Entrez Gene: WDR33 WD repeat domain 33".

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.