WDR8

WD repeat-containing protein 8 is a protein that in humans is encoded by the WDR8 gene.[5]

WRAP73
Identifiers
AliasesWRAP73, WDR8, WD repeat containing, antisense to TP73
External IDsOMIM: 606040 MGI: 1891749 HomoloGene: 9857 GeneCards: WRAP73
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p36.32Start3,630,767 bp[1]
End3,652,761 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

49856

59002

Ensembl

ENSG00000116213

ENSMUSG00000029029

UniProt

Q9P2S5

Q9JM98

RefSeq (mRNA)

NM_017818

NM_021499

RefSeq (protein)

NP_060288

NP_067474

Location (UCSC)Chr 1: 3.63 – 3.65 MbChr 4: 154.14 – 154.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification.[5]

References
  1. GRCh38: Ensembl release 89: ENSG00000116213 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029029 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: WDR8 WD repeat domain 8".

Further reading
  • Koshizuka Y, Ikegawa S, Sano M, Nakamura K, Nakamura Y (March 2001). "Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family". Genomics. 72 (3): 252–9. doi:10.1006/geno.2000.6475. PMID 11401440.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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