XPOT

Exportin-T is a protein that in humans is encoded by the XPOT gene.[5][6][7]

XPOT
Identifiers
AliasesXPOT, XPO3, exportin for tRNA
External IDsOMIM: 603180 MGI: 1920442 HomoloGene: 38291 GeneCards: XPOT
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q14.2Start64,404,392 bp[1]
End64,451,125 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11260

73192

Ensembl

ENSG00000184575

ENSMUSG00000034667

UniProt

O43592

Q9CRT8

RefSeq (mRNA)

NM_007235

NM_001081056
NM_001359618

RefSeq (protein)

NP_009166

NP_001074525
NP_001346547

Location (UCSC)Chr 12: 64.4 – 64.45 MbChr 10: 121.59 – 121.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000184575 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034667 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D (Jul 1998). "Identification of a tRNA-specific nuclear export receptor". Mol Cell. 1 (3): 359–69. doi:10.1016/S1097-2765(00)80036-2. PMID 9660920.
  6. Arts GJ, Fornerod M, Mattaj IW (May 1998). "Identification of a nuclear export receptor for tRNA". Curr Biol. 8 (6): 305–14. doi:10.1016/S0960-9822(98)70130-7. PMID 9512417. S2CID 17803674.
  7. "Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs)".

Further reading


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