YTHDF2

YTH N6-methyladenosine RNA binding protein 2 is a protein that in humans is encoded by the YTHDF2 gene. [5]

YTHDF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesYTHDF2, HGRG8, NY-REN-2, CAHL, YTH N6-methyladenosine RNA binding protein 2
External IDsOMIM: 610640 MGI: 2444233 HomoloGene: 32302 GeneCards: YTHDF2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p35.3Start28,736,621 bp[1]
End28,769,775 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

51441

213541

Ensembl

ENSG00000198492

ENSMUSG00000040025

UniProt

Q9Y5A9

Q91YT7

RefSeq (mRNA)

NM_016258
NM_001172828
NM_001173128

NM_145393

RefSeq (protein)

NP_001166299
NP_001166599
NP_057342

NP_663368

Location (UCSC)Chr 1: 28.74 – 28.77 MbChr 4: 132.18 – 132.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline-rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. Also, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively, spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012].

See also

N6-Methyladenosine

References

  1. GRCh38: Ensembl release 89: ENSG00000198492 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040025 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: YTH N6-methyladenosine RNA binding protein 2". Retrieved 2017-12-24.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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