ZC3H12A

Zinc finger CCCH-type containing 12A is a protein in humans that is encoded by the ZC3H12A gene.[5]

ZC3H12A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3V32, 3V33, 3V34
Identifiers
Aliases	ZC3H12A, MCPIP, MCPIP1, dJ423B22.1, zinc finger CCCH-type containing 12A, Reg1, MCPIP-1
External IDs	OMIM: 610562 MGI: 2385891 HomoloGene: 11824 GeneCards: ZC3H12A
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 37,474,580 bp[1] End 37,484,377 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 125,118,423 bp[2] End 125,127,840 bp[2]
Gene ontology Molecular function • miRNA binding • chromatin binding • metal ion binding • ribonuclease activity • GO:0001948 protein binding • nuclease activity • endonuclease activity • mRNA binding • hydrolase activity • ribosome binding • mRNA 3'-UTR binding • mRNA 3'-UTR AU-rich region binding • DNA binding • RNA binding • endoribonuclease activity • exoribonuclease activity • thiol-dependent ubiquitin-specific protease activity • RNA stem-loop binding Cellular component • cytoplasm • nucleoplasm • cytoskeleton • cell nucleus • extrinsic component of endoplasmic reticulum membrane • endoplasmic reticulum • rough endoplasmic reticulum membrane • rough endoplasmic reticulum • P-body • membrane • cytoplasmic ribonucleoprotein granule • macromolecular complex Biological process • positive regulation of p38MAPK cascade • cellular response to virus • cell differentiation • positive regulation of cell death • positive regulation of autophagy • negative regulation of interleukin-6 production • positive regulation of lipid storage • negative regulation of macrophage activation • cellular response to tumor necrosis factor • negative regulation of gene expression • positive regulation of angiogenesis • negative regulation of production of miRNAs involved in gene silencing by miRNA • positive regulation of endothelial cell migration • multicellular organism development • protein deubiquitination • positive regulation of gene expression • positive regulation of reactive oxygen species metabolic process • protein oligomerization • angiogenesis • regulation of gene expression • positive regulation of protein import into nucleus • negative regulation by host of viral genome replication • negative regulation of tumor necrosis factor production • positive regulation of miRNA catabolic process • negative regulation of NF-kappaB transcription factor activity • positive regulation of defense response to virus by host • apoptotic process • RNA phosphodiester bond hydrolysis, endonucleolytic • immune system process • negative regulation of muscle cell apoptotic process • negative regulation of I-kappaB kinase/NF-kappaB signaling • transcription, DNA-templated • positive regulation of fat cell differentiation • positive regulation of transcription from RNA polymerase II promoter • nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay • defense response to virus • cellular response to glucose starvation • nervous system development • negative regulation of cytokine production involved in inflammatory response • cellular response to sodium arsenite • regulation of transcription, DNA-templated • negative regulation of protein phosphorylation • cellular response to ionomycin • positive regulation of mRNA catabolic process • cellular response to lipopolysaccharide • cellular response to oxidative stress • RNA phosphodiester bond hydrolysis • negative regulation of nitric oxide biosynthetic process • cellular response to interleukin-1 • positive regulation of protein deubiquitination • cellular response to chemokine • inflammatory response • 3'-UTR-mediated mRNA destabilization • negative regulation of cardiac muscle contraction • positive regulation of execution phase of apoptosis • RNA phosphodiester bond hydrolysis, exonucleolytic • cellular response to DNA damage stimulus • immune response-activating signal transduction • negative regulation of NIK/NF-kappaB signaling • T cell receptor signaling pathway • negative regulation of T-helper 17 cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80149	230738
Ensembl	ENSG00000163874	ENSMUSG00000042677
UniProt	Q5D1E8	Q5D1E7
RefSeq (mRNA)	NM_025079 NM_001323550 NM_001323551	NM_153159
RefSeq (protein)	NP_001310479 NP_001310480 NP_079355	NP_694799
Location (UCSC)	Chr 1: 37.47 – 37.48 Mb	Chr 4: 125.12 – 125.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.